High-Frequency, Low-Intensity Vibrations Increase Bone Mass and Muscle Strength in Upper Limbs, Improving Autonomy in Disabled Children

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dc.contributor.authorReyes, M. Loreto
dc.contributor.authorHernandez, Marta
dc.contributor.authorHolmgren, Luz J.
dc.contributor.authorSanhueza, Enrique
dc.contributor.authorEscobar, Raul G.
dc.date.accessioned2024-01-10T12:05:49Z
dc.date.available2024-01-10T12:05:49Z
dc.date.issued2011
dc.description.abstractDisuse osteoporosis in children is a progressive disease that can affect quality of life. High-frequency, low-magnitude vibration (HFLMV) acts as an anabolic signal for bone and muscle. We undertook a prospective, randomized, double-blind, placebo-controlled clinical trial to assess the efficacy and safety of regional HFLMV in disabled children. Sixty-five children 6 to 9 year of age were randomized into three groups: placebo, 60 Hz, and 90 Hz. In the two active groups, a 0.3-g mechanical vibration was delivered to the radii and femurs for 5 minutes each day. After 6 months, the main endpoint was bone mineral density (BMD) at the ultradistal radius (UDR), 33% radii (33% R), and femoral necks (FN). Secondary endpoints were area and bone mineral content (BMC) at the UDR, 33% R, and FN; grip force of the upper and lower limbs; motor function; and PedsQL evaluation. An intention-to-treat analysis was used. Fifty-seven children (88%) completed the protocol. A significant increase was observed in the 60-Hz group relative to the other groups in BMD at the UDR (p=.011), in grip force of the upper limbs (p=.035), and in the "daily activities item" (p=.035). A mixed model to evaluate the response to intervention showed a stronger effect of 60 Hz on patients with cerebral palsy on the UDR and that between-subject variability significantly affected the response. There were no reported side effects of the intervention. This work provides evidence that regional HFLMV is an effective and safe strategy to improve bone mass, muscle strength, and possibly independence in children with motor disabilities. (C) 2011 American Society for Bone and Mineral Research.
dc.description.fundergovernment of Chile
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1002/jbmr.402
dc.identifier.eissn1523-4681
dc.identifier.issn0884-0431
dc.identifier.pubmedidMEDLINE:21491486
dc.identifier.urihttps://doi.org/10.1002/jbmr.402
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76073
dc.identifier.wosidWOS:000293382600009
dc.information.autorucMedicina;Escobar R;S/I;63818
dc.information.autorucMedicina;Hernandez M ;S/I;55673
dc.information.autorucMedicina;Sanhueza, E ;S/I;12248
dc.issue.numero8
dc.language.isoen
dc.nota.accesoSin adjunto
dc.pagina.final1766
dc.pagina.inicio1759
dc.publisherWILEY
dc.revistaJOURNAL OF BONE AND MINERAL RESEARCH
dc.rightsregistro bibliográfico
dc.subjectVIBRATION THERAPY
dc.subjectBONE MASS
dc.subjectMUSCLE STRENGTH
dc.subjectQUALITY OF LIFE
dc.subjectCHILDREN
dc.subjectWHOLE-BODY-VIBRATION
dc.subjectMOTOR FUNCTION
dc.subjectLOW-MAGNITUDE
dc.subjectDENSITY
dc.subjectSTIMULATION
dc.subjectRELIABILITY
dc.subjectDISEASES
dc.subjectSYSTEM
dc.subjectWOMEN
dc.subject.ods03 Good Health and Well-being
dc.subject.ods05 Gender Equality
dc.subject.odspa03 Salud y bienestar
dc.subject.odspa05 Igualdad de género
dc.titleHigh-Frequency, Low-Intensity Vibrations Increase Bone Mass and Muscle Strength in Upper Limbs, Improving Autonomy in Disabled Children
dc.typeartículo
dc.volumen26
sipa.codpersvinculados63818
sipa.codpersvinculados55673
sipa.codpersvinculados12248
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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