Is acetaminophen beneficial in patients with cancer pain who are on strong opioids? A randomized controlled trial

Leiva, Ofelia; Letelier Saavedra, Luz María; Rojas Orellana, Luis; Viviani García, Paola; Castellano, Joel; González Candia, Antonio Felipe; Pérez Cruz, Pedro

Is acetaminophen beneficial in patients with cancer pain who are on strong opioids? A randomized controlled trial

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Date

2023

Authors

Leiva, Ofelia

Letelier Saavedra, Luz María

Rojas Orellana, Luis

Viviani García, Paola

Castellano, Joel

González Candia, Antonio Felipe

Pérez Cruz, Pedro

Abstract

ContextPain is common among cancer patients. The evidence recommends using strong opioids in moderate to severe cancer pain. No conclusive evidence supports the effectiveness of adding acetaminophen to patients with cancer pain who are already using this regime.ObjectiveTo assess the analgesic efficacy of acetaminophen in hospitalized cancer patients with moderate to severe pain receiving strong opioids.MethodsIn this randomized blinded clinical trial, hospitalized cancer patients with moderate or severe acute pain managed with strong opioids were randomized to acetaminophen or placebo. The primary outcome was pain intensity difference between baseline and 48 hours using the Visual Numeric Rating Scales (VNRS). Secondary outcomes included change in morphine equivalent daily dose (MEDD), and patients’ perception of improved pain control.ResultsAmong 112 randomized patients, 56 patients received placebo, 56 acetaminophen. Mean (standard deviation (SD)) decrease in pain intensity (VNRS) at 48 hours were 2.7 (2.5) and 2.3 (2.3), respectively (95% Confidence Interval(CI) [-0.49;1.32];p=0.37). Mean (SD) change in MEDD was 13.9 (33.0) mg/day and 22.4 (57.7), respectively (95% CI [-9.24;26.1];p=0.35). The proportion of patients perceiving pain control improvement after 48 hours was 82% in the placebo and 80% in the acetaminophen arms (p=0.81).ConclusionAmong patients with cancer pain on strong opioid regime, acetaminophen may not improve pain control, or decrease total opioid use. These results add to the current evidence available suggesting not to use acetaminophen as an adjuvant for advanced cancer patients with moderate to severe cancer pain who are on strong opioids.

Keywords

Cáncer pain, Palliative care, Acetaminophen, Strong opioids, Randomized, Controlled trial

Citation

Ofelia Leiva-Vasquez , Luz M. Letelier , Luis Rojas , Paola Viviani , ´Joel Castellano , Antonio Gonzalez , Pedro E. P ´ erez-Cruz , Is acetaminophen beneficial in patients ´with cancer pain who are on strong opioids? A randomized controlled trial, Journal of Pain and Symp tom Management (2023), doi: https://doi.org/10.1016/j.jpainsymman.2023.05.002

URI

https://doi.org/10.1016/j.jpainsymman.2023.05.002
https://repositorio.uc.cl/handle/11534/70546

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