Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

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dc.contributor.authorEhret, Georg B.
dc.contributor.authorMunroe, Patricia B.
dc.contributor.authorRice, Kenneth M.
dc.contributor.authorBochud, Murielle
dc.contributor.authorJohnson, Andrew D.
dc.contributor.authorChasman, Daniel I.
dc.contributor.authorSmith, Albert V.
dc.contributor.authorTobin, Martin D.
dc.contributor.authorVerwoert, Germaine C.
dc.contributor.authorHwang, Shih Jen
dc.contributor.authorPihur, Vasyl
dc.contributor.authorVollenweider, Peter
dc.contributor.authorO'Reilly, Paul F.
dc.contributor.authorAmin, Najaf
dc.contributor.authorBragg Gresham, Jennifer L.
dc.contributor.authorTeumer, Alexander
dc.contributor.authorGlazer, Nicole L.
dc.contributor.authorLauner, Lenore
dc.contributor.authorZhao, Jing Hua
dc.contributor.authorAulchenko, Yurii
dc.contributor.authorHeath, Simon
dc.contributor.authorSober, Siim
dc.contributor.authorParsa, Afshin
dc.contributor.authorLuan, Jian'an
dc.contributor.authorArora, Pankaj
dc.contributor.authorDehghan, Abbas
dc.contributor.authorZhang, Feng
dc.contributor.authorLucas, Gavin
dc.contributor.authorHicks, Andrew A.
dc.contributor.authorJackson, Anne U.
dc.contributor.authorPeden, John F.
dc.contributor.authorTanaka, Toshiko
dc.contributor.authorWild, Sarah H.
dc.contributor.authorRudan, Igor
dc.contributor.authorIgl, Wilmar
dc.contributor.authorMilaneschi, Yuri
dc.contributor.authorParker, Alex N.
dc.contributor.authorFava, Cristiano
dc.contributor.authorChambers, John C.
dc.contributor.authorFox, Ervin R.
dc.contributor.authorKumari, Meena
dc.contributor.authorGo, Min Jin
dc.contributor.authorvan der Harst, Pim
dc.contributor.authorKao, Wen Hong Linda
dc.contributor.authorSjogren, Marketa
dc.contributor.authorVinay, D. G.
dc.contributor.authorAlexander, Myriam
dc.contributor.authorTabara, Yasuharu
dc.contributor.authorShaw Hawkins, Sue
dc.contributor.authorWhincup, Peter H.
dc.contributor.authorLiu, Yongmei
dc.contributor.authorShi, Gang
dc.contributor.authorKuusisto, Johanna
dc.contributor.authorTayo, Bamidele
dc.contributor.authorSeielstad, Mark
dc.contributor.authorSim, Xueling
dc.contributor.authorKhanh Dung Hoang Nguyen
dc.contributor.authorLehtimaki, Terho
dc.contributor.authorMatullo, Giuseppe
dc.contributor.authorWu, Ying
dc.contributor.authorGaunt, Tom R.
dc.contributor.authorOnland Moret, N. Charlotte
dc.contributor.authorCooper, Matthew N.
dc.contributor.authorPlatou, Carl G. P.
dc.contributor.authorOrg, Elin
dc.contributor.authorHardy, Rebecca
dc.contributor.authorDahgam, Santosh
dc.contributor.authorPalmen, Jutta
dc.contributor.authorVitart, Veronique
dc.contributor.authorBraund, Peter S.
dc.contributor.authorKuznetsova, Tatiana
dc.contributor.authorUiterwaal, Cuno S. P. M.
dc.contributor.authorAdeyemo, Adebowale
dc.contributor.authorPalmas, Walter
dc.contributor.authorCampbell, Harry
dc.contributor.authorLudwig, Barbara
dc.contributor.authorTomaszewski, Maciej
dc.contributor.authorTzoulaki, Ioanna
dc.contributor.authorPalmer, Nicholette D.
dc.contributor.authorAspelund, Thor
dc.contributor.authorGarcia, Melissa
dc.contributor.authorChang, Yen Pei C.
dc.contributor.authorO'Connell, Jeffrey R.
dc.contributor.authorSteinle, Nanette I.
dc.contributor.authorGrobbee, Diederick E.
dc.contributor.authorArking, Dan E.
dc.contributor.authorKardia, Sharon L.
dc.contributor.authorMorrison, Alanna C.
dc.contributor.authorHernandez, Dena
dc.contributor.authorNajjar, Samer
dc.contributor.authorMcArdle, Wendy L.
dc.contributor.authorHadley, David
dc.contributor.authorBrown, Morris J.
dc.contributor.authorConnell, John M.
dc.contributor.authorHingorani, Aroon D.
dc.contributor.authorDay, Ian N. M.
dc.contributor.authorLawlor, Debbie A.
dc.contributor.authorBeilby, John P.
dc.contributor.authorLawrence, Robert W.
dc.contributor.authorClarke, Robert
dc.contributor.authorHopewell, Jemma C.
dc.contributor.authorOngen, Halit
dc.contributor.authorDreisbach, Albert W.
dc.contributor.authorLi, Yali
dc.contributor.authorYoung, J. Hunter
dc.contributor.authorBis, Joshua C.
dc.contributor.authorKahonen, Mika
dc.contributor.authorViikari, Jorma
dc.contributor.authorAdair, Linda S.
dc.contributor.authorLee, Nanette R.
dc.contributor.authorChen, Ming Huei
dc.contributor.authorOlden, Matthias
dc.contributor.authorPattaro, Cristian
dc.contributor.authorBolton, Judith A. Hoffman
dc.contributor.authorKoettgen, Anna
dc.contributor.authorBergmann, Sven
dc.contributor.authorMooser, Vincent
dc.contributor.authorChaturvedi, Nish
dc.contributor.authorFrayling, Timothy M.
dc.contributor.authorIslam, Muhammad
dc.contributor.authorJafar, Tazeen H.
dc.contributor.authorErdmann, Jeanette
dc.contributor.authorKulkarni, Smita R.
dc.contributor.authorBornstein, Stefan R.
dc.contributor.authorGraessler, Juergen
dc.contributor.authorGroop, Leif
dc.contributor.authorVoight, Benjamin F.
dc.contributor.authorKettunen, Johannes
dc.contributor.authorHoward, Philip
dc.contributor.authorTaylor, Andrew
dc.contributor.authorGuarrera, Simonetta
dc.contributor.authorRicceri, Fulvio
dc.contributor.authorEmilsson, Valur
dc.contributor.authorPlump, Andrew
dc.contributor.authorBarroso, Ine S.
dc.contributor.authorKhaw, Kay Tee
dc.contributor.authorWeder, Alan B.
dc.contributor.authorHunt, Steven C.
dc.contributor.authorSun, Yan V.
dc.contributor.authorBergman, Richard N.
dc.contributor.authorCollins, Francis S.
dc.contributor.authorBonnycastle, Lori L.
dc.contributor.authorScott, Laura J.
dc.contributor.authorStringham, Heather M.
dc.contributor.authorPeltonen, Leena
dc.contributor.authorPerola, Markus
dc.contributor.authorVartiainen, Erkki
dc.contributor.authorBrand, Stefan Martin
dc.contributor.authorStaessen, Jan A.
dc.contributor.authorWang, Thomas J.
dc.contributor.authorBurton, Paul R.
dc.contributor.authorArtigas, Maria Soler
dc.contributor.authorDong, Yanbin
dc.contributor.authorSnieder, Harold
dc.contributor.authorWang, Xiaoling
dc.contributor.authorZhu, Haidong
dc.contributor.authorLohman, Kurt K.
dc.contributor.authorRudock, Megan E.
dc.contributor.authorHeckbert, Susan R.
dc.contributor.authorSmith, Nicholas L.
dc.contributor.authorWiggins, Kerri L.
dc.contributor.authorDoumatey, Ayo
dc.contributor.authorShriner, Daniel
dc.contributor.authorVeldre, Gudrun
dc.contributor.authorViigimaa, Margus
dc.contributor.authorKinra, Sanjay
dc.contributor.authorPrabhakaran, Dorairaj
dc.contributor.authorTripathy, Vikal
dc.contributor.authorLangefeld, Carl D.
dc.contributor.authorRosengren, Annika
dc.contributor.authorThelle, Dag S.
dc.contributor.authorCorsi, Anna Maria
dc.contributor.authorSingleton, Andrew
dc.contributor.authorForrester, Terrence
dc.contributor.authorHilton, Gina
dc.contributor.authorMcKenzie, Colin A.
dc.contributor.authorSalako, Tunde
dc.contributor.authorIwai, Naoharu
dc.contributor.authorKita, Yoshikuni
dc.contributor.authorOgihara, Toshio
dc.contributor.authorOhkubo, Takayoshi
dc.contributor.authorOkamura, Tomonori
dc.contributor.authorUeshima, Hirotsugu
dc.contributor.authorUmemura, Satoshi
dc.contributor.authorEyheramendy, Susana
dc.contributor.authorMeitinger, Thomas
dc.contributor.authorWichmann, H. Erich
dc.contributor.authorCho, Yoon Shin
dc.contributor.authorKim, Hyung Lae
dc.contributor.authorLee, Jong Young
dc.contributor.authorScott, James
dc.contributor.authorSehmi, Joban S.
dc.contributor.authorZhang, Weihua
dc.contributor.authorHedblad, Bo
dc.contributor.authorNilsson, Peter
dc.contributor.authorSmith, George Davey
dc.contributor.authorWong, Andrew
dc.contributor.authorNarisu, Narisu
dc.contributor.authorStancakova, Alena
dc.contributor.authorRaffel, Leslie J.
dc.contributor.authorYao, Jie
dc.contributor.authorKathiresan, Sekar
dc.contributor.authorO'Donnell, Christopher J.
dc.contributor.authorSchwartz, Stephen M.
dc.contributor.authorIkram, M. Arfan
dc.contributor.authorLongstreth, W. T., Jr.
dc.contributor.authorMosley, Thomas H.
dc.contributor.authorSeshadri, Sudha
dc.contributor.authorShrine, Nick R. G.
dc.contributor.authorWain, Louise V.
dc.contributor.authorMorken, Mario A.
dc.contributor.authorSwift, Amy J.
dc.contributor.authorLaitinen, Jaana
dc.contributor.authorProkopenko, Inga
dc.contributor.authorZitting, Paavo
dc.contributor.authorCooper, Jackie A.
dc.contributor.authorHumphries, Steve E.
dc.contributor.authorDanesh, John
dc.contributor.authorRasheed, Asif
dc.contributor.authorGoel, Anuj
dc.contributor.authorHamsten, Anders
dc.contributor.authorWatkins, Hugh
dc.contributor.authorBakker, Stephan J. L.
dc.contributor.authorvan Gilst, Wiek H.
dc.contributor.authorJanipalli, Charles S.
dc.contributor.authorMani, K. Radha
dc.contributor.authorYajnik, Chittaranjan S.
dc.contributor.authorHofman, Albert
dc.contributor.authorMattace Raso, Francesco U. S.
dc.contributor.authorOostra, Ben A.
dc.contributor.authorDemirkan, Ayse
dc.contributor.authorIsaacs, Aaron
dc.contributor.authorRivadeneira, Fernando
dc.contributor.authorLakatta, Edward G.
dc.contributor.authorOrru, Marco
dc.contributor.authorScuteri, Angelo
dc.contributor.authorAla Korpela, Mika
dc.contributor.authorKangas, Antti J.
dc.contributor.authorLyytikainen, Leo Pekka
dc.contributor.authorSoininen, Pasi
dc.contributor.authorTukiainen, Taru
dc.contributor.authorWurtz, Peter
dc.contributor.authorOng, Rick Twee Hee
dc.contributor.authorDoerr, Marcus
dc.contributor.authorKroemer, Heyo K.
dc.contributor.authorVoelker, Uwe
dc.contributor.authorVoelzke, Henry
dc.contributor.authorGalan, Pilar
dc.contributor.authorHercberg, Serge
dc.contributor.authorLathrop, Mark
dc.contributor.authorZelenika, Diana
dc.contributor.authorDeloukas, Panos
dc.contributor.authorMangino, Massimo
dc.contributor.authorSpector, Tim D.
dc.contributor.authorZhai, Guangju
dc.contributor.authorMeschia, James F.
dc.contributor.authorNalls, Michael A.
dc.contributor.authorSharma, Pankaj
dc.contributor.authorTerzic, Janos
dc.contributor.authorKumar, M. V. Kranthi
dc.contributor.authorDenniff, Matthew
dc.contributor.authorZukowska Szczechowska, Ewa
dc.contributor.authorWagenknecht, Lynne E.
dc.contributor.authorFowkes, F. Gerald R.
dc.contributor.authorCharchar, Fadi J.
dc.contributor.authorSchwarz, Peter E. H.
dc.contributor.authorHayward, Caroline
dc.contributor.authorGuo, Xiuqing
dc.contributor.authorRotimi, Charles
dc.contributor.authorBots, Michiel L.
dc.contributor.authorBrand, Eva
dc.contributor.authorSamani, Nilesh J.
dc.contributor.authorPolasek, Ozren
dc.contributor.authorTalmud, Philippa J.
dc.contributor.authorNyberg, Fredrik
dc.contributor.authorKuh, Diana
dc.contributor.authorLaan, Maris
dc.contributor.authorHveem, Kristian
dc.contributor.authorPalmer, Lyle J.
dc.contributor.authorvan der Schouw, Yvonne T.
dc.contributor.authorCasas, Juan P.
dc.contributor.authorMohlke, Karen L.
dc.contributor.authorVineis, Paolo
dc.contributor.authorRaitakari, Olli
dc.contributor.authorGanesh, Santhi K.
dc.contributor.authorWong, Tien Y.
dc.contributor.authorTai, E. Shyong
dc.contributor.authorCooper, Richard S.
dc.contributor.authorLaakso, Markku
dc.contributor.authorRao, Dabeeru C.
dc.contributor.authorHarris, Tamara B.
dc.contributor.authorMorris, Richard W.
dc.contributor.authorDominiczak, Anna F.
dc.contributor.authorKivimaki, Mika
dc.contributor.authorMarmot, Michael G.
dc.contributor.authorMiki, Tetsuro
dc.contributor.authorSaleheen, Danish
dc.contributor.authorChandak, Giriraj R.
dc.contributor.authorCoresh, Josef
dc.contributor.authorNavis, Gerjan
dc.contributor.authorSalomaa, Veikko
dc.contributor.authorHan, Bok Ghee
dc.contributor.authorZhu, Xiaofeng
dc.contributor.authorKooner, Jaspal S.
dc.contributor.authorMelander, Olle
dc.contributor.authorRidker, Paul M.
dc.contributor.authorBandinelli, Stefania
dc.contributor.authorGyllensten, Ulf B.
dc.contributor.authorWright, Alan F.
dc.contributor.authorWilson, James F.
dc.contributor.authorFerrucci, Luigi
dc.contributor.authorFarrall, Martin
dc.contributor.authorTuomilehto, Jaakko
dc.contributor.authorPramstaller, Peter P.
dc.contributor.authorElosua, Roberto
dc.contributor.authorSoranzo, Nicole
dc.contributor.authorSijbrands, Eric J. G.
dc.contributor.authorAltshuler, David
dc.contributor.authorLoos, Ruth J. F.
dc.contributor.authorShuldiner, Alan R.
dc.contributor.authorGieger, Christian
dc.contributor.authorMeneton, Pierre
dc.contributor.authorUitterlinden, Andre G.
dc.contributor.authorWareham, Nicholas J.
dc.contributor.authorGudnason, Vilmundur
dc.contributor.authorRotter, Jerome I.
dc.contributor.authorRettig, Rainer
dc.contributor.authorUda, Manuela
dc.contributor.authorStrachan, David P.
dc.contributor.authorWitteman, Jacqueline C. M.
dc.contributor.authorHartikainen, Anna Liisa
dc.contributor.authorBeckmann, Jacques S.
dc.contributor.authorBoerwinkle, Eric
dc.contributor.authorVasan, Ramachandran S.
dc.contributor.authorBoehnke, Michael
dc.contributor.authorLarson, Martin G.
dc.contributor.authorJarvelin, Marjo Riitta
dc.contributor.authorPsaty, Bruce M.
dc.contributor.authorAbecasis, Goncalo R.
dc.contributor.authorChakravarti, Aravinda
dc.contributor.authorElliott, Paul
dc.contributor.authorvan Duijn, Cornelia M.
dc.contributor.authorNewton Cheh, Christopher
dc.contributor.authorLevy, Daniel
dc.contributor.authorCaulfield, Mark J.
dc.contributor.authorJohnson, Toby
dc.contributor.authorInt Consortium Blood Pressure Geno
dc.contributor.authorCARDIoGRAM Consortium
dc.contributor.authorCKDGen Consortium
dc.contributor.authorKidneyGen Consortium
dc.contributor.authorEchoGen Consortium
dc.contributor.authorCHARGE HF Consortium
dc.date.accessioned2024-01-10T13:13:17Z
dc.date.available2024-01-10T13:13:17Z
dc.date.issued2011
dc.description.abstractBlood pressure is a heritable trait(1) influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (>= 140 mm Hg systolic blood pressure or >= 90 mm Hg diastolic blood pressure)(2). Even small increments in blood pressure are associated with an increased risk of cardiovascular events(3). This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3-GUCY1B3, NPR3-C5orf23, ADM, FURIN-FES, GOSR2, GNAS-EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention.
dc.description.funderNIH/NHLBI
dc.description.funderAustrian Science Fund (FWF)
dc.description.funderBritish Heart Foundation
dc.description.funderKidney Research UK
dc.description.funderMedical Research Council
dc.description.funderNational Institute for Health Research
dc.description.funderChief Scientist Office
dc.description.funderAGENCY FOR HEALTHCARE RESEARCH AND QUALITY
dc.description.funderDIVISION OF EPIDEMIOLOGY AND CLINICAL APPLICATIONS
dc.description.funderEUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT
dc.description.funderFOGARTY INTERNATIONAL CENTER
dc.description.funderNATIONAL CANCER INSTITUTE
dc.description.funderNATIONAL CENTER FOR RESEARCH RESOURCES
dc.description.funderNATIONAL HEART, LUNG, AND BLOOD INSTITUTE
dc.description.funderNATIONAL HUMAN GENOME RESEARCH INSTITUTE
dc.description.funderNATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH
dc.description.funderNATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
dc.description.funderNATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
dc.description.funderNATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
dc.description.funderNATIONAL INSTITUTE OF MENTAL HEALTH
dc.description.funderNATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
dc.description.funderNATIONAL INSTITUTE ON AGING
dc.description.funderNational Institute on Minority Health and Health Disparities
dc.description.funderGrants-in-Aid for Scientific Research
dc.fechaingreso.objetodigital2024-05-02
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1038/nature10405
dc.identifier.eissn1476-4687
dc.identifier.issn0028-0836
dc.identifier.pubmedidMEDLINE:21909115
dc.identifier.urihttps://doi.org/10.1038/nature10405
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78288
dc.identifier.wosidWOS:000295575400043
dc.information.autorucMatemática;Eyheramendy S;S/I;82611
dc.issue.numero7367
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final109
dc.pagina.inicio103
dc.publisherNATURE PUBLISHING GROUP
dc.revistaNATURE
dc.rightsacceso restringido
dc.subjectGENOME-WIDE ASSOCIATION
dc.subjectCOMMON VARIANTS
dc.subjectHYPERTENSION
dc.subjectLOCI
dc.subjectMETAANALYSIS
dc.subjectPOPULATION
dc.subjectCLONING
dc.subjectHEALTH
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleGenetic variants in novel pathways influence blood pressure and cardiovascular disease risk
dc.typeartículo
dc.volumen478
sipa.codpersvinculados82611
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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