Risk factors associated with faecal carriage of extended-spectrum cephalosporin-resistant<i> Escherichia</i><i> coli</i> among dogs in Southeast Brazil

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dc.contributor.authorSalgado-Caxito, Marilia
dc.contributor.authorBenavides, Julio A.
dc.contributor.authorMunita, Jose M.
dc.contributor.authorRivas, Lina
dc.contributor.authorGarcia, Patricia
dc.contributor.authorListoni, Fernando J. P.
dc.contributor.authorMoreno-Switt, Andrea, I
dc.contributor.authorPaes, Antonio C.
dc.date.accessioned2025-01-20T23:50:40Z
dc.date.available2025-01-20T23:50:40Z
dc.date.issued2021
dc.description.abstractFaecal carriage of extended-spectrum cephalosporin-resistant Escherichia coli (ESC-R E. coli) in dogs has been reported worldwide and can reduce the effectiveness of treatments against bacterial infections. However, the drivers that influence faecal carriage of ESC-R E. coli in dogs are poorly understood. The aims of this study were to estimate the prevalence of ESC-R E. coli among dogs prior to their admission to a veterinary teaching hospital and to identify risk factors associated with the faecal carriage of ESC-R E. coli. Rectal swabs (n = 130) were collected from dogs and screened for ESC-R E. coli using MacConkey agar supplemented with cefotaxime (2 ?g/ mL). E. coli species was confirmed by MALDI-TOF and screening of extended-spectrum beta-lactamase (ESBL) genes was conducted by multiplex PCR. Questionnaires were completed by each dog?s owner to test several human and dog characteristics associated with ESC-R E. coli. The prevalence of faecal carriage of ESC-R E. coli was 9.2 % and 67 % of ESC-R E. coli isolates harboured ESBL genes including CTX-M alone or in combination with TEM. All ESC-R E. coli isolates were resistant to ceftriaxone, cefpodoxime, and cefotaxime and were sus-ceptible to cefoxitin and carbapenems. The likelihood of carrying ESC-R E. coli was 15 times higher (OR = 14.41 [95 % CI: 1.80-38.02], p < 0.01) if the dog was treated with antibiotics 3?12 months prior to sampling and 8 times higher (OR = 7.96 [95 % CI: 2.96-92.07], p < 0.01) if the dog had direct contact with livestock, but 15 times lower (OR = 0.07 [95 % CI: 0.01-0.32], p < 0.01) if the dog was dewormed during the previous year. Our findings confirm the faecal carriage of ESC-R E. coli in subclinical dogs and call for further investigation regarding the impact of deworming on antibiotic-resistant bacteria in companion animals.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.prevetmed.2021.105316
dc.identifier.eissn1873-1716
dc.identifier.issn0167-5877
dc.identifier.urihttps://doi.org/10.1016/j.prevetmed.2021.105316
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/94730
dc.identifier.wosidWOS:000641974800005
dc.language.isoen
dc.revistaPreventive veterinary medicine
dc.rightsacceso restringido
dc.subjectAntimicrobial resistance
dc.subjectCompanion animals
dc.subjectDeworming
dc.subjectE
dc.subjectcoli
dc.subjectExtended-spectrum beta-lactamase
dc.subjectLatin America
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleRisk factors associated with faecal carriage of extended-spectrum cephalosporin-resistant<i> Escherichia</i><i> coli</i> among dogs in Southeast Brazil
dc.typeartículo
dc.volumen190
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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