Comparison of Lipoprotein-Associated Phospholipase A2 and High Sensitive C-Reactive Protein as Determinants of Metabolic Syndrome in Subjects without Coronary Heart Disease: In Search of the Best Predictor

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dc.contributor.authorAcevedo, Monica
dc.contributor.authorVarleta, Paola
dc.contributor.authorKramer, Veronica
dc.contributor.authorValentino, Giovanna
dc.contributor.authorQuiroga, Teresa
dc.contributor.authorPrieto, Carolina
dc.contributor.authorParada, Jacqueline
dc.contributor.authorAdasme, Marcela
dc.contributor.authorBriones, Luisa
dc.contributor.authorNavarrete, Carlos
dc.date.accessioned2024-01-10T13:47:02Z
dc.date.available2024-01-10T13:47:02Z
dc.date.issued2015
dc.description.abstractHigh sensitivity C-reactive protein (hsCRP) is a marker of metabolic syndrome (MS) and cardiovascular (CV) disease. Lipoproteinassociated phospholipase A2 (Lp-PLA2) also predicts CV disease. There are no reports comparing these markers as predictors of MS. Methods. Cross-sectional study comparing Lp-PLA2 and hsCRP as predictors of MS in asymptomatic subjects was carried out; 152 subjects without known atherosclerosis participated. Data were collected on demographics, cardiovascular risk factors, anthropometric and biochemical measurements, and hsCRP and Lp-PLA2 activity levels. A logistic regression analysis was performed with each biomarker and receiver operating characteristic (ROC) curves were constructed for MS. Results. Mean age was 46 +/- 11 years, and 38% of the subjects had MS. Mean Lp-PLA2 activity was 185 +/- 48 nmol/mL/min, and mean hsCRP was 2.1 +/- 2.2mg/L. Subjects with MS had significantly higher levels of Lp-PLA2 (P = 0.03) and hsCRP (P < 0.0001) than those without MS. ROC curves showed that both markers predictedMS. Conclusion. Lp-PLA2 and hsCRP are elevated in subjects withMS. Both biomarkers were independent and significant predictors for MS, emphasizing the role of inflammation in MS. Further research is necessary to determine if inflammation predicts a higher risk for CV events in MS subjects.
dc.fechaingreso.objetodigital2024-05-10
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1155/2015/934681
dc.identifier.eissn1687-8345
dc.identifier.issn1687-8337
dc.identifier.pubmedidMEDLINE:26089902
dc.identifier.urihttps://doi.org/10.1155/2015/934681
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79228
dc.identifier.wosidWOS:000355469800001
dc.information.autorucMedicina;Acevedo M ;S/I;81173
dc.information.autorucMedicina;Adasme M;S/I;132711
dc.information.autorucMedicina;Kramer V;S/I;4946
dc.information.autorucMedicina;Parada J;S/I;117371
dc.information.autorucCiencias de la Salud;Quiroga T ;S/I;215818
dc.information.autorucMedicina;Valentino G ;S/I;1012072
dc.language.isoen
dc.nota.accesocontenido completo
dc.publisherHINDAWI LTD
dc.revistaINTERNATIONAL JOURNAL OF ENDOCRINOLOGY
dc.rightsacceso abierto
dc.subjectRISK
dc.subjectATHEROSCLEROSIS
dc.subjectOBESITY
dc.subjectA(2)
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleComparison of Lipoprotein-Associated Phospholipase A2 and High Sensitive C-Reactive Protein as Determinants of Metabolic Syndrome in Subjects without Coronary Heart Disease: In Search of the Best Predictor
dc.typeartículo
dc.volumen2015
sipa.codpersvinculados81173
sipa.codpersvinculados132711
sipa.codpersvinculados4946
sipa.codpersvinculados117371
sipa.codpersvinculados215818
sipa.codpersvinculados1012072
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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