Synthesis, characterization and biological activity of platinum(II) complexes with a tetrapyrazole ligand

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dc.contributor.authorHiguera Padilla, Angel R.
dc.contributor.authorCapote, Jorlis
dc.contributor.authorOrtega, Dianela
dc.contributor.authorCastro, William
dc.contributor.authorRodriguez Cordero, Mildred
dc.contributor.authorColl, David
dc.contributor.authorHernandez Medina, Fernando
dc.contributor.authorFernandez Mestre, Mercedes
dc.contributor.authorUrdanibia, Izaskun
dc.contributor.authorTaylor, Peter
dc.contributor.authorRodriguez, Barbara
dc.contributor.authorKaram, Arquimedes
dc.date.accessioned2024-01-10T12:09:06Z
dc.date.available2024-01-10T12:09:06Z
dc.date.issued2015
dc.description.abstractIn the search of an effective chemotherapy for the treatment of cancer, in this work we describe the synthesis, characterization and biological activity of two new platinum complexes. The general formula is [Pt-2(L)(X)(4)], where L was 1,2,4,5-tetrakis((1H-pyrazol-1-yl)methyl)benzene and X were iodine (1) and chlorine (2). The most probable structure was established through a combination of spectroscopic analysis and density functional theory (DFT) calculations. Studies of interaction of complexes with DNA were carried out, and the results by spectroscopic titrations, thermal denaturation and viscosity, showed noncovalent interactions of complexes with DNA. The comet assay showed damage to cellular DNA Inhibition assays of thioredoxin reductase (TrxR) were carried out, and the compounds showed notable inhibitory activity on the enzyme in a concentration dependent manner, with IC50 values of 3.9 and 3.5 nM for 1 and 2 respectively. Complex 2 exhibited greater inhibitory effects than complex 1 against all the tumor cell lines, with growth inhibitory effects superior to cisplatin in some cases. (C) 2015 Elsevier Ltd. All rights reserved.
dc.fechaingreso.objetodigital08-04-2024
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.poly.2015.09.065
dc.identifier.issn0277-5387
dc.identifier.urihttps://doi.org/10.1016/j.poly.2015.09.065
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76459
dc.identifier.wosidWOS:000367757100042
dc.information.autorucQuímica;Rodriguez B;S/I;250654
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final328
dc.pagina.inicio321
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.revistaPOLYHEDRON
dc.rightsacceso restringido
dc.subjectAnticancer activity
dc.subjectPlatinum complexes
dc.subjectDNA
dc.subjectThioredoxin reductase
dc.subjectTetrapyrazole ligand
dc.subjectMETAL-BASED CHEMOTHERAPY
dc.subjectDNA-BINDING
dc.subjectKETOCONAZOLE COMPLEXES
dc.subjectTHIOREDOXIN REDUCTASE
dc.subjectTROPICAL DISEASES
dc.subjectGOLD COMPOUNDS
dc.subjectCYTOTOXICITY
dc.subjectCOPPER(II)
dc.subjectAGENTS
dc.subjectCLOTRIMAZOLE
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSynthesis, characterization and biological activity of platinum(II) complexes with a tetrapyrazole ligand
dc.typeartículo
dc.volumen102
sipa.codpersvinculados250654
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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