Synthesis of 2-aminobenzophenone-based Schiff base Pd(II) complexes: Investigation on crystal structure, biological behavior of DNA/protein-binding, molecular docking, and<i>in vitro</i>anticancer activities

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dc.contributor.authorSatheeshkumar, Rajendran
dc.contributor.authorWu, Jing
dc.contributor.authorChandrasekaran, Rajamanickam
dc.contributor.authorRevathi, Kannan
dc.contributor.authorSparkes, Hazel A.
dc.contributor.authorWang, Wen-Long
dc.date.accessioned2025-01-23T19:51:05Z
dc.date.available2025-01-23T19:51:05Z
dc.date.issued2020
dc.description.abstractTwo new monobasic bidentate ligands and their Pd(II) complexes have been synthesized and characterized by analytical and spectroscopic methods. The structures of the complexes were confirmed by single-crystal X-ray diffraction. The bimolecular binding of the ligands and complexes has been carried out and described. Interestingly, both the bidentate chelating ligands replaced all the triphenyl arsine and chloride ions from the metal precursor in the formation of new complexes and were found to be approximately square planar. The interaction of the ligands and the complexes with calf thymus DNA and bovine serum albumin was studied by electronic and emission spectroscopy techniques, which suggested an intercalation mode of binding. It is well-known that the viscosity of a DNA solution increases if any compound added binds to it through intercalation because this process lengthens the DNA helix due to the increased separation of the DNA base pairs when the compound slides in between, whereas a partial, nonclassical intercalation could bend (or kink) the DNA helix, which leads to a reduction in length and thereby reducing its viscosity. By contrast, there will be no change in the viscosity when the compounds bind with DNA grooves or by partial intercalation, which was further confirmed by viscosity measurements and molecular docking studies. It has been found that the compounds cleaved supercoiled DNA into nicked DNA without any external agent. Thein vitrocytotoxicity studies of the ligands and complexes against human lung (A549) and breast (MCF7) cancer cell lines showed significant activity for both species.
dc.fuente.origenWOS
dc.identifier.doi10.1002/aoc.5856
dc.identifier.eissn1099-0739
dc.identifier.issn0268-2605
dc.identifier.urihttps://doi.org/10.1002/aoc.5856
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100566
dc.identifier.wosidWOS:000543357600001
dc.issue.numero10
dc.language.isoen
dc.revistaApplied organometallic chemistry
dc.rightsacceso restringido
dc.subjectcytotoxicity
dc.subjectDNA
dc.subjectprotein binding
dc.subjectPd(II) complexes
dc.subjectSchiff base ligands
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSynthesis of 2-aminobenzophenone-based Schiff base Pd(II) complexes: Investigation on crystal structure, biological behavior of DNA/protein-binding, molecular docking, and<i>in vitro</i>anticancer activities
dc.typeartículo
dc.volumen34
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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