Brain stem metastases treated with radiosurgery: prognostic factors of survival and life expectancy estimation

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dc.contributor.authorLorenzoni, Jose G.
dc.contributor.authorDevriendt, Daniel
dc.contributor.authorMassager, Nicolas
dc.contributor.authorDesmedt, Francoise
dc.contributor.authorSimon, Stephane
dc.contributor.authorVan Houtte, Paul
dc.contributor.authorBrotchi, Jacques
dc.contributor.authorLevivier, Marc
dc.date.accessioned2024-01-10T13:11:31Z
dc.date.available2024-01-10T13:11:31Z
dc.date.issued2009
dc.description.abstractBackground: The objective of this study is to study prognostic factors of survival and 3 stratification systems for life expectancy estimation in patients with brain stem metastases treated with radiosurgery.
dc.description.abstractMethods: Between December 1999 and November 2006, 25 patients with 27 brain stem metastases were treated with Gamma Knife radiosurgery. The lesions' mean volume was 0.6 mL (0.013-3.6 mL). The mean marginal dose was 20 Gy (15-24 Gy). Univariate and multivariate studies were done to identify prognostic factors, and 3 patient stratification systems were applied for survival estimation: RPA, SIR, and BSBM.
dc.description.abstractResults: The primary turner location was in the lungs in 12 patients, breast in 8, and other in 5. Fourteen lesions were located in the pons, 9 in the midbrain, and 4 in the medulla. All patients were followed clinically. Radiologic follow-up was available in 21 lesions (78%). Tumor control was achieved in all but one followed lesion (95%). There were no complications related to treatment. Median survival of patients with brain stem metastases was 11.1 months. In multivariate analysis, KPS of 80 or more, control of the primary tumor, absence of radiotherapy, and a marginal dose higher than 18 Gy were associated with better survival., The BSBM in the univariate and multivariate analyses was the strongest predictor of survival (P < .0001).
dc.description.abstractConclusions: The BSBM was the most useful tool for estimating survival. Rather than the brain stem location of an intracranial metastasis, the patient integral clinical status seems to be more important in determining survival. (C) 2009 Elsevier Inc. All rights reserved.
dc.fechaingreso.objetodigital11-04-2024
dc.format.extent9 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.surneu.2008.01.029
dc.identifier.issn0090-3019
dc.identifier.pubmedidMEDLINE:18439658
dc.identifier.urihttps://doi.org/10.1016/j.surneu.2008.01.029
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78055
dc.identifier.wosidWOS:000262895900008
dc.information.autorucMedicina;Lorenzoni J;S/I;80739
dc.issue.numero2
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final196
dc.pagina.inicio188
dc.publisherELSEVIER SCIENCE INC
dc.revistaSURGICAL NEUROLOGY
dc.rightsacceso restringido
dc.subjectRadiosurgery
dc.subjectBrain stem
dc.subjectMetastases
dc.subjectStratification
dc.subjectSurvival
dc.subjectRECURSIVE PARTITIONING ANALYSIS
dc.subjectGAMMA-KNIFE RADIOSURGERY
dc.subjectSTEREOTACTIC RADIOSURGERY
dc.subjectRADIATION-THERAPY
dc.subjectANALYSIS RPA
dc.subjectTUMORS
dc.subjectCLASSIFICATION
dc.subjectEXPERIENCE
dc.subjectMANAGEMENT
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleBrain stem metastases treated with radiosurgery: prognostic factors of survival and life expectancy estimation
dc.typeartículo
dc.volumen71
sipa.codpersvinculados80739
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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