Amerindian ancestry proportion as a risk factor for inflammatory bowel diseases: results from a Latin American Andean cohort

Simple item page
dc.catalogadordfo
dc.contributor.authorPérez Jeldres, Tamara De Lourdes
dc.contributor.authorMagne, Fabien
dc.contributor.authorAscui, Gabriel
dc.contributor.authorAlvares, Danilo
dc.contributor.authorOrellana, Matias
dc.contributor.authorÁlvarez Lobos Manuel Marcelo
dc.contributor.authorHernández Rocha, Cristián Antonio
dc.contributor.authorAzocar, Lorena
dc.contributor.authorAguilar, Nataly
dc.contributor.authorEspino, Alberto
dc.contributor.authorEstela, Ricardo
dc.contributor.authorEscobar, Sergio
dc.contributor.authorZazueta, Alejandra
dc.contributor.authorBaez, Pablo
dc.contributor.authorSilva, Veronica
dc.contributor.authorde la Vega, Andres
dc.contributor.authorArriagada, Elizabeth
dc.contributor.authorPávez Ovalle, Carolina Denisse
dc.contributor.authorDiaz-Asencio, Alejandro
dc.contributor.authorTravisany, Dante
dc.contributor.authorMiquel Poblete, Juan Francisco
dc.contributor.authorVillablanca, Eduardo J.
dc.contributor.authorKronenberg, Mitchell
dc.contributor.authorBustamante, Maria Leonor
dc.date.accessioned2024-08-09T16:42:21Z
dc.date.available2024-08-09T16:42:21Z
dc.date.issued2023
dc.description.abstractBackground and aimsLatin American populations remain underrepresented in genetic studies of inflammatory bowel diseases (IBDs). Most genetic association studies of IBD rely on Caucasian, African, and Asian individuals. These associations have yet to be evaluated in detail in the Andean region of South America. We explored the contribution of IBD-reported genetic risk variants to a Chilean cohort and the ancestry contribution to IBD in this cohort.MethodsA total of 192 Chilean IBD patients were genotyped using Illumina's Global Screening Array. Genotype data were combined with similar information from 3,147 Chilean controls. The proportions of Aymara, African, European, and Mapuche ancestries were estimated using the software ADMIXTURE. We calculated the odds ratios (ORs) and 95% confidence intervals (CIs) for gender, age, and ancestry proportions. We also explored associations with previously reported IBD-risk variants independently and in conjunction with genetic ancestry.ResultsThe first and third quartiles of the proportion of Mapuche ancestry in IBD patients were 24.7 and 34.2%, respectively, and the corresponding OR was 2.30 (95%CI 1.52-3.48) for the lowest vs. the highest group. Only one variant (rs7210086) of the 180 reported IBD-risk SNPs was associated with IBD risk in the Chilean cohort (adjusted P = 0.01). This variant is related to myeloid cells.ConclusionThe type and proportion of Native American ancestry in Chileans seem to be associated with IBD risk. Variants associated with IBD risk in this Andean region were related to myeloid cells and the innate immune response.
dc.fuente.origenWOS
dc.identifier.doi10.3389/fmed.2023.1258395
dc.identifier.eissn2296-858X
dc.identifier.urihttps://doi.org/10.3389/fmed.2023.1258395
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/87397
dc.identifier.wosidWOS:001100891800001
dc.information.autorucEscuela de Medicina; Perez Jeldres Tamara De Lourdes; S/I; 1024946
dc.information.autorucEscuela de Medicina; Alvarez Lobos Manuel Marcelo; S/I; 6131
dc.information.autorucEscuela de Medicina; Hernandez Rocha Cristian Antonio; 0000-0001-9018-4242; 175117
dc.information.autorucEscuela de Medicina; Pavez Ovalle Carolina Denisse; S/I; 190170
dc.information.autorucEscuela de Medicina; Miquel Poblete Juan Francisco; 0000-0002-0526-4377; 72216
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final12
dc.pagina.inicio1
dc.revistaFrontiers in medicine
dc.rightsacceso abierto
dc.rights.licenseAtribution 4.0 Inernational (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectInflammatory bowel disease
dc.subjectSingle nucleotide polymorphism (SNP)
dc.subjectAncestry
dc.subjectLatin American
dc.subjectGenetics
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAmerindian ancestry proportion as a risk factor for inflammatory bowel diseases: results from a Latin American Andean cohort
dc.typeartículo
dc.volumen10
sipa.codpersvinculados1024946
sipa.codpersvinculados6131
sipa.codpersvinculados175117
sipa.codpersvinculados190170
sipa.codpersvinculados72216
sipa.trazabilidadWOS;2023-12-16
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
fmed-10-1258395.pdf
Size:
897.5 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Artículos de revistas