Frequency of diminished ovarian reserve in women with multiple sclerosis in Chile: An exploratory study

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dc.article.number105012
dc.catalogadoraba
dc.contributor.authorPelayo Carolina
dc.contributor.authorCiampi Díaz, Ethel Leslie
dc.contributor.authorSoler León, Bernardita María
dc.contributor.authorUribe San Martín, Reinaldo Moises
dc.contributor.authorReyes Delgado, Ana Cecilia
dc.contributor.authorGarcía, Lorena
dc.contributor.authorDel Canto, Adolfo
dc.contributor.authorGutiérrez Carquin, Leticia
dc.contributor.authorBarrerra Hormazabal, Antonia
dc.contributor.authorJurgensen Heinrich, Lukas
dc.contributor.authorGuzman Cárcamo, Ignacio
dc.contributor.authorCarvajal, Andrés
dc.contributor.authorTroncoso, Carlos
dc.contributor.authorCarvajal, Rodrigo
dc.contributor.authorCárcamo Rodríguez, Claudia Andrea
dc.date.accessioned2024-01-17T19:36:04Z
dc.date.available2024-01-17T19:36:04Z
dc.date.issued2023
dc.description.abstractIntroduction: Multiple Sclerosis (MS) is a chronic disease affecting around 2.8 million people worldwide. Two-thirds are women, and the mean age at diagnosis is about 30 years old. Social trends are moving towards older age at first pregnancy, both in women with and without MS. Objectives: To determine the frequency of diminished ovarian reserve (DOR) through anti-Mullerian Hormone (AMH) measurement in women with MS at fertile age and Healthy Females (HF) in Chile. Methods: Case-control, multicentric, cross-sectional study including relapsing-remitting people with MS (pwMS) between 18 and 40 years and sex and age-matched HF. We obtained a blood sample to determine AMH levels. We defined DOR as AMH <1.5 ng/mL and very-low AMH levels as <0.5 ng/mL. Also, we performed questions regarding reproductive decision-making. Results: We included 79 sex and age-matched HF and 92 pwMS, median age 32(19–40) years, median disease duration 6 (1–17)years, median EDSS 1.0 (0–6), 95% were receiving disease-modifying therapy (DMT), 70% high-efficacy DMT and 37% with a treatment that contraindicates pregnancy. DOR was observed in 24% (n = 22) of the pwMS, compared to 14% (n = 11) of the HF (p = 0.09), while very-low AMH levels were observed in 7.6% (n = 7) of pwMS and none of the HF (p = 0.0166). We observed an inverse correlation between age and AMH levels. Age was the only significant risk factor for low AMH levels in pwMS (OR 1.14 95%CI(1.00–1–31), p = 0.04), including smoking, body mass index (BMI), hormonal contraception, autoimmune comorbidity, high/low-moderate efficacy DMT, and active disease as covariables. We did not find statistically significant differences in age at diagnosis, BMI, disease duration, EDSS, autoimmune comorbidity, use of hormonal contraception, or percentage of active disease between MS women with normal vs DOR. Over 70% of pwMS desired to become pregnant in the future, while 60% considered that the diagnosis of MS was a limitation for pregnancy planning. Conclusions: No differences in DOR, measured by levels of AMH, were observed between pwMS MS and HF in Chile. As expected, AMH levels were correlated only with ageing. This information may be evaluated early during the disease course to help patients and neurologists with fertility counselling and family planning considerations regarding DMT use.
dc.fechaingreso.objetodigital2024-01-19
dc.format.extent7 páginas
dc.fuente.origenORCID-ene24
dc.identifier.doi10.1016/j.msard.2023.105012
dc.identifier.eissn2211-0356
dc.identifier.issn2211-0348
dc.identifier.scopusidSCOPUS_ID:85173190515
dc.identifier.urihttps://doi.org/10.1016/j.msard.2023.105012
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80567
dc.information.autorucEscuela de Medicina; Ciampi Díaz, Ethel Leslie; 0000-0002-7330-5433; 132794
dc.information.autorucEscuela de Medicina; Soler León, Bernardita María; 0000-0002-8143-4497; 189547
dc.information.autorucEscuela de Medicina; Uribe San Martín, Reinaldo Moises; 0000-0002-3422-7962; 127201
dc.information.autorucEscuela de Medicina; Reyes Delgado, Ana Cecilia; S/I; 1013047
dc.information.autorucEscuela de Medicina; Cárcamo Rodríguez, Claudia Andrea; 0000-0002-9430-216X; 562
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final7
dc.pagina.inicio1
dc.revistaMultiple Sclerosis and Related Disorders
dc.rightsacceso restringido
dc.subjectAnti-mullerian hormone
dc.subjectDiminished ovarian reserve
dc.subjectFertility
dc.subjectOvarian ageing
dc.subjectOvarian reserve
dc.subjectRelapsing-remitting multiple sclerosis
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleFrequency of diminished ovarian reserve in women with multiple sclerosis in Chile: An exploratory study
dc.typeartículo
dc.volumen79
sipa.codpersvinculados132794
sipa.codpersvinculados189547
sipa.codpersvinculados127201
sipa.codpersvinculados1013047
sipa.codpersvinculados562
sipa.indexSCOPUS
sipa.trazabilidadORCID;2024-01-08
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