Etiología y biomarcadores de inflamación sistémica en las exacerbaciones leves a moderadas de la enfermedad pulmonar obstructiva crónica

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dc.contributor.authorSaldias P, Fernando
dc.contributor.authorDiaz P, Orlando
dc.contributor.authorDreyse D, Jorge
dc.contributor.authorGaggero B, Aldo
dc.contributor.authorSandoval A, Christian
dc.contributor.authorLisboa B, Carmen
dc.date.accessioned2024-01-10T12:38:46Z
dc.date.available2024-01-10T12:38:46Z
dc.date.issued2012
dc.description.abstractBackground: The etiology of acute exacerbations of chronic obstructive pulmonary disease (COPD) is heterogeneous and still under discussion. Inflammation increases during exacerbation of COPD. The identification of inflammatory changes will increase our knowledge and potentially guide therapy. Aim: To identify which inflammatory parameters increase during COPD exacerbations compared to stable disease, and to compare bacterial and viral exacerbations. Material and Methods: In 85 COPD patients (45 males, mean age 68 +/- 8 years, FEV, 46 +/- 17% of predicted) sputum, nasopharyngeal swabs and blood samples were collected to identify the causative organism, during a mild to moderate exacerbation. Serum ultrasensitive C reactive protein (CRP), fibrinogen and interleukin 6 (IL 6), neutrophil and leukocyte counts were measured in stable conditions, during a COPD exacerbation, 15 and 30 days post exacerbation. Results: A total of 120 mild to moderate COPD exacerbations were included. In 74 (61.7%), a microbial etiology could be identified, most commonly Mycoplasma pneumoniae (15.8%), Rhinovirus (15%), Haemophilus influenzae (14.2%), Chlamydia pneumoniae (11.7%), Streptococcus pneumoniae (5.8%) and Gram negative bacilli (5.8%). Serum CRP, fibrinogen and IL 6, and neutrophil and leukocyte counts significantly increased during exacerbation and recovered at 30 days post exacerbation. Compared to viral exacerbations, bacterial aggravations were associated with a systemic inflammation of higher magnitude. Conclusions: Biomarkers of systemic inflammation increase during mild to moderate COPD exacerbations. The increase in systemic inflammation seems to be limited to exacerbations caused by bacterial infections. (Rev Med Chile 2012; 140: 10-18).
dc.fechaingreso.objetodigital2024-05-31
dc.format.extent9 páginas
dc.fuente.origenWOS
dc.identifier.doi10.4067/S0034-98872012000100002
dc.identifier.eissn0717-6163
dc.identifier.issn0034-9887
dc.identifier.pubmedidMEDLINE:22552550
dc.identifier.urihttps://doi.org/10.4067/S0034-98872012000100002
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77096
dc.identifier.wosidWOS:000301221700002
dc.information.autorucMedicina;Diaz O ;S/I;78564
dc.information.autorucMedicina;Lisboa C ;S/I;98551
dc.information.autorucMedicina;Saldias F ;S/I;67197
dc.issue.numero1
dc.language.isoes
dc.nota.accesoContenido parcial
dc.pagina.final18
dc.pagina.inicio10
dc.publisherSOC MEDICA SANTIAGO
dc.revistaREVISTA MEDICA DE CHILE
dc.rightsacceso restringido
dc.subjectC-reactive protein
dc.subjectInflammation
dc.subjectPulmonary disease chronic obstructive
dc.subjectOBSTRUCTIVE PULMONARY-DISEASE
dc.subjectQUALITY-OF-LIFE
dc.subjectAIRWAY INFLAMMATION
dc.subjectRESPIRATORY VIRUSES
dc.subjectCHRONIC-BRONCHITIS
dc.subjectLUNG-DISEASE
dc.subjectINFECTION
dc.subjectBACTERIAL
dc.subjectSPUTUM
dc.subjectRHINOVIRUS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEtiología y biomarcadores de inflamación sistémica en las exacerbaciones leves a moderadas de la enfermedad pulmonar obstructiva crónica
dc.title.alternativeEtiology and biomarkers of systemic inflammation in mild to moderate COPD exacerbations
dc.typeartículo
dc.volumen140
sipa.codpersvinculados78564
sipa.codpersvinculados98551
sipa.codpersvinculados67197
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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