Dietary Crocin is Protective in Pancreatic Cancer while Reducing Radiation-Induced Hepatic Oxidative Damage

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dc.contributor.authorBakshi, Hamid A.
dc.contributor.authorAl Zoubi, Mazhar S.
dc.contributor.authorFaruck, Hakkim L.
dc.contributor.authorAljabali, Alaa A. A.
dc.contributor.authorRabi, Firas A.
dc.contributor.authorHafiz, Amin A.
dc.contributor.authorAl-Batanyeh, Khalid M.
dc.contributor.authorAl-Trad, Bahaa
dc.contributor.authorAnsari, Prawej
dc.contributor.authorNasef, Mohamed M.
dc.contributor.authorCharbe, Nitin B.
dc.contributor.authorSatija, Saurabh
dc.contributor.authorMehta, Meenu
dc.contributor.authorMishra, Vijay
dc.contributor.authorGupta, Gaurav
dc.contributor.authorAbobaker, Salem
dc.contributor.authorNegi, Poonam
dc.contributor.authorAzzouz, Ibrahim M.
dc.contributor.authorDardouri, Ashref Ali K.
dc.contributor.authorDureja, Harish
dc.contributor.authorPrasher, Parteek
dc.contributor.authorChellappan, Dinesh K.
dc.contributor.authorDua, Kamal
dc.contributor.authorDa Silva, Mateus Webba
dc.contributor.authorEl Tanani, Mohamed
dc.contributor.authorMcCarron, Paul A.
dc.contributor.authorTambuwala, Murtaza M.
dc.date.accessioned2025-01-23T19:49:42Z
dc.date.available2025-01-23T19:49:42Z
dc.date.issued2020
dc.description.abstractPancreatic cancer is one of the fatal causes of global cancer-related deaths. Although surgery and chemotherapy are standard treatment options, post-treatment outcomes often end in a poor prognosis. In the present study, we investigated anti-pancreatic cancer and amelioration of radiation-induced oxidative damage by crocin. Crocin is a carotenoid isolated from the dietary herb saffron, a prospect for novel leads as an anti-cancer agent. Crocin significantly reduced cell viability of BXPC3 and Capan-2 by triggering caspase signaling via the downregulation of Bcl-2. It modulated the expression of cell cycle signaling proteins P53, P21, P27, CDK2, c-MYC, Cyt-c and P38. Concomitantly, crocin treatment-induced apoptosis by inducing the release of cytochrome c from mitochondria to cytosol. Microarray analysis of the expression signature of genes induced by crocin showed a substantial number of genes involved in cell signaling pathways and checkpoints (723) are significantly affected by crocin. In mice bearing pancreatic tumors, crocin significantly reduced tumor burden without a change in body weight. Additionally, it showed significant protection against radiation-induced hepatic oxidative damage, reduced the levels of hepatic toxicity and preserved liver morphology. These findings indicate that crocin has a potential role in the treatment, prevention and management of pancreatic cancer.
dc.fuente.origenWOS
dc.identifier.doi10.3390/nu12061901
dc.identifier.eissn2072-6643
dc.identifier.urihttps://doi.org/10.3390/nu12061901
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100514
dc.identifier.wosidWOS:000553534600001
dc.issue.numero6
dc.language.isoen
dc.revistaNutrients
dc.rightsacceso restringido
dc.subjectpancreatic cancer
dc.subjectcrocin
dc.subjectapoptosis
dc.subjectcell cycle
dc.subjectradiation
dc.subjecthepatic injury
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleDietary Crocin is Protective in Pancreatic Cancer while Reducing Radiation-Induced Hepatic Oxidative Damage
dc.typeartículo
dc.volumen12
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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