A new era in oxygen therapeutics?: from perfluorocarbon systems to haemoglobin-based oxygen carriers

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dc.article.number100927
dc.catalogadorpva
dc.contributor.authorCharbe, N.B.
dc.contributor.authorCastillo, F.
dc.contributor.authorTambuwala, M.M.
dc.contributor.authorChellappan, D.K.
dc.contributor.authorCarreƱo, A.
dc.contributor.authorSatija, S.
dc.contributor.authorSingh, S.K.
dc.contributor.authorGulati, M.
dc.contributor.authorDua, K.
dc.contributor.authorGonzalez-Aramundiz, J.V.
dc.date.accessioned2023-08-22T19:51:50Z
dc.date.available2023-08-22T19:51:50Z
dc.date.issued2022
dc.description.abstractBlood transfusion is the key to life in case of traumatic emergencies, surgeries and in several pathological conditions. An important goal of whole blood or red blood cell transfusion is the fast delivery of oxygen to vital organs and restoration of circulation volume. Whole blood or red blood cell transfusion has several limitations. Free haemoglobin not only loses its tetrameric configuration and extracts via the kidney leading to nephrotoxicity but also scavenges nitric oxide (NO), leading to vasoconstriction and hypertension. PFC based formulations transport oxygen in vivo, the contribution in terms of clinical outcome is challenging. The oxygen-carrying capacity is not the only criterion for the successful development of haemoglobin-based oxygen carriers (HBOCs). This review is a bird's eye view on the present state of the PFCs and HBOCs in which we analyzed the current modifications made or which are underway in development, their promises, and hurdles in clinical implementation.
dc.description.funderANID
dc.description.funderCONICYT FONDECYT
dc.description.funderMinisterio de Ciencia TecnologĆ­a e InnovaciĆ³n
dc.description.funderCOLCIENCIAS
dc.fechaingreso.objetodigital2023-08-22
dc.fuente.origenSCOPUS
dc.identifier.doi10.1016/j.blre.2022.100927
dc.identifier.eissn15321681
dc.identifier.issn0268-960X
dc.identifier.scopusidSCOPUS_ID:85123713657
dc.identifier.urihttps://doi.org/10.1016/j.blre.2022.100927
dc.identifier.urihttp://www.elsevier.com/locate/issn/0268960X
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/74452
dc.information.autorucEscuela de QuĆ­mica; Zacconi Flavia Cristina Milagro; 0000-0002-3676-0453; 1011127
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final23
dc.pagina.inicio1
dc.publisherChurchill Livingstone
dc.relation.ispartofBlood Reviews
dc.revistaBlood Reviewses_ES
dc.rightsacceso restringido
dc.subjectBlood transfusiones_ES
dc.subjectHaemoglobin-based oxygen carriers (HBOCs)es_ES
dc.subjectNitric oxide scavenginges_ES
dc.subjectPerfluorocarbons (PFCs)es_ES
dc.subjectRecombinant haemoglobines_ES
dc.subjectVasoconstrictiones_ES
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleA new era in oxygen therapeutics?: from perfluorocarbon systems to haemoglobin-based oxygen carrierses_ES
dc.typeartĆ­culo
dc.volumen54
sipa.codpersvinculados1011127
sipa.indexSCOPUS
sipa.indexWOS
sipa.trazabilidadSCOPUS;21-03-2022
sipa.trazabilidadORCID;2023-08-21
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