Correlation between Ki67 and histological grade in breast cancer patients treated with preoperative chemotherapy

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dc.catalogadorpva
dc.contributor.authorPetric Guajardo, Militza Paulina
dc.contributor.authorMartínez Riquelme, Santiago Felipe
dc.contributor.authorAcevedo Claros, Francisco Nicolás
dc.contributor.authorOddo Benavides, David
dc.contributor.authorArtigas Barrenechea, Rocío
dc.contributor.authorCamus Appuhn, Mauricio Gonzalo
dc.contributor.authorSánchez Rojel, César Giovanni
dc.date.accessioned2024-01-19T18:21:51Z
dc.date.available2024-01-19T18:21:51Z
dc.date.issued2014
dc.description.abstractBackground and Aim: Breast cancer (BC) is a heterogeneous disease and cell proliferation markers may help to identify subtypes of clinical interest. We here analyzed the correlation between cell proliferation determined by Ki67 and HG in BC patients undergoing preoperative chemotherapy (PCT). Materials and Methods: We obtained clinical/pathological data from patients with invasive BC treated at our institution from 1999 until 2012. Expression of estrogen receptor (ER), progesterone receptor (PR), epidermal growth factor receptor type 2 (HER2) and Ki67 were determined by immuno-histochemistry (IHC). Clinicopathological subtypes were defined as: Luminal A, ER and/or PR positive, HER2 negative, HG 1 or 2; Luminal B, ER and/or PR positive, HER2 negative or positive and/or HG 3; triple negative (TN), ER, PR and HER2 negative independent of HG; HER2 positive, ER, PR negative and HER2 positive, independent of HG. By using Ki67, a value of 14% separated Luminal A and B tumors, independently of the histological grade. We analyzed correlations between Ki67 and HG, to define BC subtypes and their predictive value for response to PCT. Results: 1,560 BC patients were treated in the period, 147 receiving PCT (9.5%). Some 57 had sufficient clinicopathological information to be included in the study. Median age was 52 years (26-72), with 87.7% invasive ductal carcinomas (n=50). We performed IHC for Ki67 in 40 core biopsies and 50 surgical biopsies, 37 paired samples with Ki67 before and after chemotherapy being available. There was no significant correlation between Ki67 and HG (p=0.237), both categorizing patients into different subtypes. In most cases Ki67 decreased after PCT (65.8%). Only 3 patients had pathologic complete response (cPR). Conclusions: In our experience we did not find associations between Ki67 and HG. Determination of clinicopathological luminal subtypes differs by using Ki67 or HG.
dc.fechaingreso.objetodigital2024-01-30
dc.fuente.origenORCID-ene24
dc.identifier.doi10.7314/apjcp.2014.15.23.10277
dc.identifier.eissn2476-762X
dc.identifier.issn1513-7368
dc.identifier.urihttp://dx.doi.org/10.7314/apjcp.2014.15.23.10277
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80816
dc.information.autorucEscuela de Medicina; Petric Guajardo, Militza Paulina; S/I; 218626
dc.information.autorucEscuela de Medicina; Martínez Riquelme, Santiago Felipe; S/I; 209506
dc.information.autorucEscuela de Medicina; Acevedo Claros, Francisco Nicolás; 0000-0003-3482-7746; 119540
dc.information.autorucEscuela de Medicina; Oddo Benavides, David; 0000-0002-3974-7393; 102247
dc.information.autorucEscuela de Medicina; Artigas Barrenechea, Rocío; 0000-0003-0092-2390; 9174
dc.information.autorucEscuela de Medicina; Camus Appuhn, Mauricio Gonzalo; 0000-0002-8409-5240; 100235
dc.information.autorucEscuela de Medicina; Sánchez Rojel, César Giovanni; 0000-0002-2920-108X; 135644
dc.issue.numero23
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final10280
dc.pagina.inicio10277
dc.revistaAsian Pacific Journal of Cancer Preventiones_ES
dc.rightsacceso abierto
dc.subjectBreast canceres_ES
dc.subjectKi67 indexes_ES
dc.subjectBiological markerses_ES
dc.subjectMolecular subtypeses_ES
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleCorrelation between Ki67 and histological grade in breast cancer patients treated with preoperative chemotherapyes_ES
dc.typeartículo
dc.volumen15
sipa.codpersvinculados218626
sipa.codpersvinculados209506
sipa.codpersvinculados119540
sipa.codpersvinculados102247
sipa.codpersvinculados9174
sipa.codpersvinculados100235
sipa.codpersvinculados135644
sipa.trazabilidadORCID;2024-01-08
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