Physiological Functions of Glial Cell Hemichannels

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dc.catalogadorjlo
dc.contributor.authorOrellana Roca, Juan Andrés
dc.date.accessioned2024-10-14T19:59:49Z
dc.date.available2024-10-14T19:59:49Z
dc.date.issued2016
dc.description.abstractThe brain performs exceptionally complex and dynamic tasks that depend on the coordinated interaction of neurons, glial cells, endothelial cells, pericytes, smooth muscle cells, ependymal cells, and circulating blood cells. Among these cells, glial cells have emerged as crucial protagonists in the regulation of synaptic transmission and neural function. Indeed, these cells express a wide range of receptors that enable them to sense changes in neuronal activity and the microenvironment by responding locally via the release of bioactive molecules known as gliotransmitters. In the central nervous system (CNS), a novel mechanism that allows gliotransmission via the opening of hemichannels has been proposed. These channels are composed of six protein subunits consisting of connexins or pannexins, which are two highly conserved protein families that are encoded by 21 and 3 genes, respectively, in humans. Typically, glial cell hemichannels exhibit low levels of activity, but this activity is sufficient to ensure the release of a broad spectrum of gliotransmitters, including ATP, D-serine, glutamate, adenosine, and glutathione. Here, we briefly review the current findings regarding the effects of the hemichannel-dependent release of gliotransmitters on the physiology of the CNS.
dc.format.extent16 páginas
dc.fuente.origenConveris
dc.identifier.doi10.1007/978-3-319-40764-7_5
dc.identifier.issn0065-2598
dc.identifier.pubmedid27714686
dc.identifier.scopusid84991383807
dc.identifier.urihttps://doi.org/10.1007/978-3-319-40764-7_5
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/88209
dc.identifier.wosidWOS:000400932800005
dc.information.autorucEscuela de Medicina; Orellana Roca, Juan Andrés; 0000-0003-4076-207X; 126007
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final108
dc.pagina.inicio93
dc.publisherSpringer
dc.relation.ispartofGlial Cells in Health and Disease of the CNS
dc.rightsacceso restringido
dc.subjectConnexins
dc.subjectPannexins
dc.subjectAstroglial signaling
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titlePhysiological Functions of Glial Cell Hemichannels
dc.typecapítulo de libro
dc.volumen949
sipa.codpersvinculados126007
sipa.trazabilidadConveris;20-07-2021
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