Dynamics of cortical computations underlying attentive states

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dc.contributor.advisorOssandón, Tomás
dc.contributor.authorMedel Sierralta, Vicente
dc.contributor.otherPontificia Universidad Católica de Chile. Facultad de Medicina
dc.date.accessioned2021-11-29T20:45:37Z
dc.date.available2021-11-29T20:45:37Z
dc.date.issued2021
dc.date.updated2021-11-26T17:26:28Z
dc.descriptionTesis (Doctor of Philosophy in Neuroscience)--Pontificia Universidad Católica de Chile, 2021
dc.description.abstractSpontaneous fluctuations occur at different spatial and temporal scales in the brain. Depending on its scale, these activities can show characteristic hallmarks. From a mesoscale perspective, in spontaneous conditions, cortical neurons fire action potentials in a seemingly stochastic manner, which extrapolated to an entire population shows a dynamical state coined as the asynchronous irregular state. Interestingly, when a local population of balanced excitation and inhibition is recurrently connected, the asynchronous population generates a baseline of stochastic perturbation over the neuron’s membrane potential of that local population. These perturbations have been proposed as optimal for information computation and are associated with different states of attention at the behavioral level. Specifically, Locus-Coeruleus Noradrenergic (LC-NE) neuromodulation -which regulates brain states- has been highly implicated in the modulation of desynchronized activity. In this dissertation, we will use a modeling-driven analysis of attentional modulation of local electrophysiological desynchronization, hypothesizing that LC-NE neuromodulation shapes desynchronized background state and the balance between excitation and inhibition. We will show how the complexity of the electrophysiological signals depends on the excitation-inhibition balance of cortical activity, how it tracks behavioral performance, and how it can be related to LC-NE activity and arousal-related neuromodulation. Finally, we show how this complexity fluctuates at different spatial scales with low-dimensionality in attention, and how it is tracked by pupil diameter fluctuations -a non-invasive proxy of LC-NE activity and arousal- in a visuospatial working memory task in humans.
dc.description.version2021-11-30
dc.format.extent204 páginas
dc.fuente.origenAutoarchivo
dc.identifier.doi10.7764/tesisUC/MED/62985
dc.identifier.urihttps://doi.org/10.7764/tesisUC/MED/62985
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/62985
dc.information.autorucFacultad de Medicina ; Ossandón, Tomás ; 0000-0002-7306-7754 ; 1011810
dc.information.autorucFacultad de Medicina ; Medel Sierralta, Vicente ; 0000-0003-2443-8683 ; 1049792
dc.language.isoen
dc.nota.accesoContenido completo
dc.rightsacceso abierto
dc.subjectEstados corticaleses_ES
dc.subject.ddc612.8
dc.subject.deweyMedicina y saludes_ES
dc.subject.otherLocus coeruleuses_ES
dc.subject.otherSistema nerviosoes_ES
dc.subject.otherNeurofisiologíaes_ES
dc.titleDynamics of cortical computations underlying attentive stateses_ES
dc.typetesis doctoral
sipa.codpersvinculados1011810
sipa.codpersvinculados1049792
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