Constructing Simple Biological Networks for Understanding Complex High-Throughput Data in Plants

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dc.catalogadorjwg
dc.contributor.authorVidal Olate, Elena Alejandra
dc.contributor.authorContreras López, Luis Orlando
dc.contributor.authorGutiérrez Ilabaca, Rodrigo Antonio
dc.contributor.authorMoyano Yugovic, Tomás Custodio
dc.contributor.editorStepanova, Anna N.
dc.date.accessioned2024-01-31T13:48:45Z
dc.date.available2024-01-31T13:48:45Z
dc.date.issued2015
dc.description.abstractTechnological advances in the last decade have enabled biologists to produce increasing amounts of information for the transcriptome, proteome, interactome, and other -omics data sets in many model organisms. A major challenge is integration and biological interpretation of these massive data sets in order to generate testable hypotheses about gene regulatory networks or molecular mechanisms that govern system behaviors. Constructing gene networks requires bioinformatics skills to adequately manage, integrate, analyze and productively use the data to generate biological insights. In this chapter, we provide detailed methods for users without prior knowledge of bioinformatics to construct gene networks and derive hypotheses that can be experimentally verified. Step-by-step instructions for acquiring, integrating, analyzing, and visualizing genome-wide data are provided for two widely used open source platforms, R and Cytoscape platforms. The examples provided are based on Arabidopsis data, but the protocols presented should be readily applicable to any organism for which similar data can be obtained.
dc.description.funderOtro
dc.description.funderHHMI
dc.fuente.origenHistorial Académico
dc.identifier.citationTomas C. Moyano, Elena A. Vidal, Orlando Contreras-López, Rodrigo A. Gutiérrez. Constructing Simple Biological Networks for Understanding Complex High-Throughput Data in Plants. In: José M. Alonso and Anna N. Stepanova,editors. Plant Functional Genomics: Methods and Protocols, Methods in Molecular Biology. New York: Springer; 2015. p. 503-526.
dc.identifier.isbn978-1-4939-2443
dc.identifier.urihttp://link.springer.com/protocol/10.1007%2F978-1-4939-2444-8_25
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/81110
dc.identifier.wosidWOS:000372659000026
dc.information.autorucFacultad de Ciencias Biológicas; Contreras Lopez Luis Orlando; S/I;149770
dc.information.autorucFacultad de Ciencias Biológicas; Moyano Yugovic Tomas Custodio; 0000-0001-6495-4995; 49778
dc.information.autorucFacultad de Ciencias Biológicas; Vidal Olate Elena Alejandra; ; 119466
dc.information.autorucFacultad de Ciencias Biológicas; Gutierrez Ilabaca Rodrigo Antonio; 0000-0002-5961-5005; 86782
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final526
dc.pagina.inicio503
dc.publisherSpringer
dc.relation.ispartofPlant Functional Genomics: Methods and Protocols, Methods in Molecular Biology
dc.rightsacceso restringido
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods02 Zero Hunger
dc.subject.odspa02 Hambre cero
dc.titleConstructing Simple Biological Networks for Understanding Complex High-Throughput Data in Plants
dc.typecapítulo de libro
dc.volumen1284
sipa.codpersvinculados149770
sipa.codpersvinculados149778
sipa.codpersvinculados119466
sipa.codpersvinculados86782
sipa.trazabilidadORCID;2024-01-15
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