Molecular analysis of the adaptive response of intestinal bile acid transport after ileal resection in the rat

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dc.contributor.authorCoppola, CP
dc.contributor.authorGosche, JR
dc.contributor.authorArrese, M
dc.contributor.authorAncowitz, B
dc.contributor.authorMadsen, J
dc.contributor.authorVanderhoof, J
dc.contributor.authorShneider, BL
dc.date.accessioned2024-01-10T12:40:33Z
dc.date.available2024-01-10T12:40:33Z
dc.date.issued1998
dc.description.abstractBackground & Aims: The apical sodium-dependent bile acid transporter is critical for intestinal reclamation of bile salts, Its expression and activity, along with the ileal lipid-binding protein, were studied before and after intestinal resection in the rat. Methods: The effects of surgical resection and bile acid feeding on the expression of ileal bile acid transport were assessed by a combination of functional (taurocholate uptake into crude brush border membrane vesicles) and molecular assays (Northern and Western blotting), Results: Transport, apical sodium-dependent bile acid transporter and ileal lipid-binding protein messenger RNA and protein expression were restricted to the distal 30 cm of ileum. After resection, transport and expression were limited to the remaining portions of this segment, Limited ileal resection increased protein mass and, therefore, transport in the terminal 5 cm of ileum without a specific increase in transporter gene expression, increased bile acid presentation to the terminal ileum did not induce ileal hyperplasia. Eighty-five percent intestinal resection led to ileal hypertrophy and a specific repression in bile acid transport activity. Conclusions: Native and compensatory bile acid transporter gene expression occur predominantly in the terminal 30 cm of ileum. The specific ileal responses to intestinal resection are dependent on the extent of resection.
dc.description.funderNIDDK NIH HHS
dc.description.funderNATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
dc.fechaingreso.objetodigital16-04-2024
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/S0016-5085(98)70088-5
dc.identifier.eissn1528-0012
dc.identifier.issn0016-5085
dc.identifier.pubmedidMEDLINE:9797372
dc.identifier.urihttps://doi.org/10.1016/S0016-5085(98)70088-5
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77323
dc.identifier.wosidWOS:000076664900024
dc.information.autorucMedicina;Arrese M;S/I;76095
dc.issue.numero5
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final1178
dc.pagina.inicio1172
dc.publisherW B SAUNDERS CO-ELSEVIER INC
dc.revistaGASTROENTEROLOGY
dc.rightsacceso restringido
dc.subjectBOWEL RESECTION
dc.subjectEXPRESSION
dc.subjectABSORPTION
dc.subjectPROTEIN
dc.subjectBINDING
dc.subjectCHOLESTEROL
dc.subjectADAPTATION
dc.subjectILEUM
dc.subjectTRANSCRIPTION
dc.subjectEPITHELIUM
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMolecular analysis of the adaptive response of intestinal bile acid transport after ileal resection in the rat
dc.typeartículo
dc.volumen115
sipa.codpersvinculados76095
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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