Neural tube defects prevalence does not increase aftermodification of the folic acid fortification program in Chile

Simple item page
dc.catalogadordfo
dc.contributor.authorPardo, Rosa
dc.contributor.authorVilca, Marcela
dc.contributor.authorVillarroel del Pino, Luis A.
dc.contributor.authorDavalji, Tahera
dc.contributor.authorObrycki, John F.
dc.contributor.authorMazumdar, Maitreyi
dc.contributor.authorÁvila, Claudia
dc.contributor.authorMellado Sagredo, Cecilia
dc.date.accessioned2024-01-22T16:22:21Z
dc.date.available2024-01-22T16:22:21Z
dc.date.issued2022
dc.description.abstractBackground:In 2000, Chile’s Ministry of Health mandated fortification ofwheat flour with folic acid at a concentration of 2.2 mg/kg to prevent neuraltube defects (NTDs), resulting in a 50% reduction in NTD prevalence. Con-cerns about possible collateral effects of high folic acid intake led, in 2009, todecrease the folic acid fortification to 1.8 mg/kg of flour. Our study evaluatedthe impact of this modification on the prevalence of NTDs in Santiago.Methods:This study measured the prevalence of NTDs in live births and still-births born in Santiago. We calculated prevalence ratios (PR) and 95% confi-dence intervals (CI) between pre-folic acid fortification (1999–2000), post-folicacid fortification (2001–2009), and post-modified folic acid fortification (2010–2015) periods for all NTDs and their specific types. We used chi-square tests toanalyze proportions, and a Joinpoint regression to visualize prevalence timetrends.Results:The NTD prevalence for the period 2001–2015 was 8.9 per 10,000births, which represents a 48% reduction (PR=0.52; 95% CI=0.45–0.61;p< .001) from the pre-folic acid fortification period. During 2010–2015, theNTD prevalence was 9.5/10,000 births, which was higher, but not statisticallysignificantly different from 2001 to 2009 prevalence of 8.6/10,000 (PR=1.11;95% CI=0.96–1.30,p=.17).Conclusions:Decreasing the concentration of folic acid fortification was notassociated with a statistically significant change in the prevalence of NTDs.Mandatory folic acid fortification continues to be a safe and highly effectivepolicy to prevent NTDs. Future studies should evaluate the prevalence ofNTDs across Chile and adherence to folic acid fortification mandates
dc.fuente.origenORCID-ene24
dc.identifier.doi10.1002/bdr2.1994
dc.identifier.issn2472-1727
dc.identifier.urihttps://doi.org/10.1002/bdr2.1994
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80893
dc.information.autorucEscuela de Medicina; Villarroel del Pino, Luis A.; 0000-0001-9603-937X; 77182
dc.information.autorucEscuela de Medicina; Mellado Sagredo, Cecilia; 0000-0002-6032-4651; 1002671
dc.issue.numero7
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final266
dc.pagina.inicio259
dc.revistaBirth Defects Research
dc.rightsacceso restringido
dc.subjectChile
dc.subjectFolic acid
dc.subjectFortification
dc.subjectNeural tube defects
dc.subject.ddc600
dc.subject.deweyTecnologíaes_ES
dc.titleNeural tube defects prevalence does not increase aftermodification of the folic acid fortification program in Chile
dc.typeartículo
dc.volumen114
sipa.codpersvinculados77182
sipa.codpersvinculados1002671
sipa.trazabilidadWOS;18-03-2022
Files
Collections
Artículos de revistas