Therapeutic Drug Monitoring of Mycophenolic Acid in Kidney Transplant Patients: A Abbreviated Sampling Strategy

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dc.catalogadorpau
dc.contributor.authorMuller, H.
dc.contributor.authorSolari Gajardo, Sandra
dc.contributor.authorZuniga, C.
dc.contributor.authorGuerra Venegas, Irene Del Carmen
dc.contributor.authorTroncoso, J.
dc.contributor.authorOvalle, R.
dc.contributor.authorMorente, J.
dc.contributor.authorPedreros, C.
dc.date.accessioned2023-05-19T20:25:23Z
dc.date.available2023-05-19T20:25:23Z
dc.date.issued2007
dc.description.abstractMycophenolic acid (MPA) levels have demonstrated a good correlation with clinical outcomes, but with great pharmacokinetic variability between patients. Therapeutic drug monitoring (TDM) is recommended to include a 12-hour area under the concentration–time curve (AUC). Since full AUC estimates are not practical for routine monitoring, limited sampling strategies have been suggested. We evaluated MPA pharmacokinetics in 18 stable renal transplant patients receiving mycophenolate mofetil (MMF) as part of their immunosuppressive therapy. The correlation between measured and estimated AUC was assessed using 4 different sparse sampling algorithms. The mean values for C0 and AUC0–6h were 1.8 ± 1.2 mg/L and 31.1 ± 14.8 mg*h/L, respectively. The dose-corrected AUC0–6h was 35.4 ± 17.9 mg*h/L. Regarding the single time points, C0 showed a low correlation with AUC0–6h (r2 = .34); C1.5, the best correlation (r2 = .72); and C3, the worst (r2 = .07). Sparse sample algorithms used to estimate 12-hour AUC including C0, C1, C2, C3, C4, and/or C6 showed a good correlation with the calculated AUC0–6 (r2 = .81–.96). The algorithm that used C0, C1, C2, and C4 showed the best correlation, but we also found a good correlation (r2 = .91) with C0, C1, and C2. Based on these results, we have suggested using the 3-point algorithm (C0, C1, and C2) for MPA TDM in stable renal transplant patients due to the good correlation with drug exposure and better functionality than an algorithm using a 4-hour postdose measurement.
dc.fechaingreso.objetodigital2023-07-06
dc.format.extent4 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1016/j.transproceed.2006.12.027
dc.identifier.issn0041-1345
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/67386
dc.information.autorucEscuela de Medicina; Solari Gajardo, Sandra; S/I; 1871
dc.information.autorucEscuela de Medicina; Guerra Venegas, Irene Del Carmen; S/I; 117495
dc.issue.numero3
dc.language.isoen
dc.nota.accesoContenido parcial
dc.revistaTransplantation Proceedings
dc.rightsacceso restringido
dc.titleTherapeutic Drug Monitoring of Mycophenolic Acid in Kidney Transplant Patients: A Abbreviated Sampling Strategyes_ES
dc.typeartículo
dc.volumen39
sipa.codpersvinculados1871
sipa.codpersvinculados117495
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