Exploring the Genetic Diversity of Epstein–Barr Virus among Patients with Gastric Cancer in Southern Chile

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dc.catalogadorpau
dc.contributor.authorReyes, María Elena
dc.contributor.authorZanella, Louise
dc.contributor.authorRiquelme, Ismael
dc.contributor.authorBuchegger, Kurt
dc.contributor.authorMora-Lagos, Bárbara
dc.contributor.authorGuzmán, Pablo
dc.contributor.authorGarcía Cañete, Patricia
dc.contributor.authorRoa Strauch, Juan Carlos Enrique
dc.contributor.authorGloria Ili, Carmen
dc.contributor.authorBrebi, Priscilla
dc.date.accessioned2023-07-21T17:46:21Z
dc.date.available2023-07-21T17:46:21Z
dc.date.issued2023
dc.description.abstractThe Epstein–Barr virus (EBV) has been associated with gastric cancer (GC), one of the deadliest malignancies in Chile and the world. Little is known about Chilean EBV strains. This study aims to investigate the frequency and genetic diversity of EBV in GC in patients in southern Chile. To evaluate the prevalence of EBV in GC patients from the Chilean population, we studied 54 GC samples using the gold standard detection method of EBV-encoded small RNA (EBER). The EBV-positive samples were subjected to amplification and sequencing of the Epstein–Barr virus nuclear protein 3A (EBNA3A) gene to evaluate the genetic diversity of EBV strains circulating in southern Chile. In total, 22.2% of the GC samples were EBV-positive and significantly associated with diffuse-type histology (p = 0.003). Phylogenetic analyses identified EBV-1 and EBV-2 in the GC samples, showing genetic diversity among Chilean isolates. This work provides important information for an epidemiological follow-up of the different EBV subtypes that may cause GC in southern Chile.
dc.fechaingreso.objetodigital2023-07-21
dc.format.extent13 páginas
dc.fuente.origenORCID
dc.identifier.doi10.3390/ijms241411276
dc.identifier.issn1422-0067
dc.identifier.urihttps://doi.org/10.3390/ijms241411276
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/74301
dc.information.autorucEscuela de Medicina ; García Cañete, Patricia ; 0000-0002-3817-4896 ; 73909
dc.information.autorucEscuela de Medicina ; Roa Strauch, Juan Carlos Enrique ; 0000-0001-8313-8774 ; 84743
dc.issue.numero14
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final13
dc.pagina.inicio1
dc.revistaInternational Journal of Molecular Scienceses_ES
dc.rightsacceso abierto
dc.subjectGastric cancer
dc.subjectEpstein–Barr virus (EBV)
dc.subjectEBNA3A
dc.subjectPhylogeny
dc.subjectChile
dc.titleExploring the Genetic Diversity of Epstein–Barr Virus among Patients with Gastric Cancer in Southern Chilees_ES
dc.typeartículo
dc.volumen24
sipa.codpersvinculados73909
sipa.codpersvinculados84743
sipa.trazabilidadORCID;2023-07-17
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