Is familial lupus different from sporadic lupus? Data from LUMINA (LXXIII), a multiethnic US cohort

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dc.contributor.authorBurgos, P. I.
dc.contributor.authorMcGwin, G., Jr.
dc.contributor.authorReveille, J. D.
dc.contributor.authorVila, L. M.
dc.contributor.authorBrown, E. E.
dc.contributor.authorAlarcon, G. S.
dc.date.accessioned2024-01-10T12:06:13Z
dc.date.available2024-01-10T12:06:13Z
dc.date.issued2010
dc.description.abstractThe aim of this study was to characterize the clinical features of familial lupus, and determine its influence on damage accrual and survival using data from LUMINA, a longitudinal multiethnic US cohort. Familial lupus was defined as patients with a first-degree relative with systemic lupus erythematosus. Relative risks were estimated by logistic regression; odds ratios (ORs) and their 95% confidence intervals (CIs) were the measure of association for familial lupus. Hazard ratios were calculated using Cox proportional hazards adjusted for potential confounders for damage and survival. Of 644 patients, 32 had familial and 612 had sporadic lupus; both groups were of comparable age (similar to 36 years). Patients with familial lupus were, in decreasing order of frequency, siblings, parents and children. In multivariable analyses, mucosal ulcers (OR = 1.92, 95% CI 0.65-5.70), mitral valve prolapse (OR = 1.74, 95% CI 0.50-6.10), cerebrovascular disease (OR = 4.18, 95% CI 0.98-17.76) and oral contraceptive use (ever/never; OR = 2.51, 95% CI 0.88-7.19) were more likely in familial lupus, but a history of low platelet count (<150,000/mm(3); OR = 0.31, 95% CI 0.08-1.17) and pulmonary disease activity (OR = 0.39, 95% CI 0.14-1.20) were less likely. However, none of these associations reached statistical significance. Familial lupus was not significantly associated with a shorter time to either damage accrual or death (HR = 0.77, 95% CI 0.37-1.59, p = 0.4746 and HR = 0.20, 95% CI 0.03-1.47, p = 0.2020, respectively). We conclude that although some clinical differences were observed between patients with familial and sporadic lupus, familial lupus was not associated with a significantly greater disease burden (damage, survival) than sporadic lupus. Lupus (2010) 19, 1331-1336.
dc.description.funderNational Institute of Arthritis and Musculoskeletal and Skin Disease
dc.description.funderGeneral Clinical Research Centers
dc.description.funderNational Center for Research Resources (NCRR/HIH) RCMI Clinical Research Infrastructure Initiative (RCRII)
dc.description.funderPrograma de Postgrado Becas Chile
dc.description.funderNATIONAL CENTER FOR RESEARCH RESOURCES
dc.description.funderNATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES
dc.fechaingreso.objetodigital2024-05-20
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1177/0961203310375264
dc.identifier.issn0961-2033
dc.identifier.pubmedidMEDLINE:20696771
dc.identifier.urihttps://doi.org/10.1177/0961203310375264
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76131
dc.identifier.wosidWOS:000282090700009
dc.information.autorucMedicina;Burgos PI;S/I;93093
dc.issue.numero11
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final1336
dc.pagina.inicio1331
dc.publisherSAGE PUBLICATIONS LTD
dc.revistaLUPUS
dc.rightsacceso restringido
dc.subjectfamilial lupus
dc.subjectlupus
dc.subjectsporadic lupus
dc.subjectLUMINA
dc.subjectmultiethnic cohort
dc.subject3 ETHNIC-GROUPS
dc.subjectERYTHEMATOSUS
dc.subjectRELIABILITY
dc.subjectFEATURES
dc.subjectINDEX
dc.subjectONSET
dc.subjectSLE
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleIs familial lupus different from sporadic lupus? Data from LUMINA (LXXIII), a multiethnic US cohort
dc.typeartículo
dc.volumen19
sipa.codpersvinculados93093
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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