Evaluación de la insulinemia post carga oral de glucosa como método diagnóstico de resistencia a la insulina

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dc.catalogadordfo
dc.contributor.authorArancibia, Constanza
dc.contributor.authorGalgani Fuentes, José
dc.contributor.authorValderas Igor, Juan Patricio
dc.contributor.authorMorales, Mauricio
dc.contributor.authorSantos Martin, José Luis
dc.contributor.authorPollak Cornejo, Felipe
dc.date.accessioned2024-01-12T18:37:50Z
dc.date.available2024-01-12T18:37:50Z
dc.date.issued2014
dc.description.abstractBackground: In our country, the assessment of insulin resistance (IR) measuring serum insulin levels at 60 and 120 minutes after a 75 g oral glucose tolerance test (OGTT), is usual. However, there is no information about the distribution of serum insulin levels in the Chilean population. Aim: To assess the distribution of serum insulin levels at 60 and 120 minutes during OGTTs and suggest a statistical cut-off point to estimate the degree of IR. Material and Methods: Retrospective analysis of 1815 OGTTs performed in non-diabetic subjects aged between 18 and 75 years, at a university medical center. HOMA-IR (Homeostasis Model Assessment), insulin sensitivity index of Matsuda (ISI-Composite), and their correlation with serum insulin levels at 60 and 120 minutes were calculated. Results: The 75th percentiles for serum insulin levels at 60 and 120 minutes were 127 and 81 μU/mL, respectively. There was a high correlation between HOMA-IR and ISI-Composite (r = -089, p < 0.001). There was a weaker although significant correlation between HOMA-IR and ISI-Composite and insulin levels at 60 (r = 0.56 and -0.79 respectively, p < 0,001) and 120 minutes (r = 0.54 and -0.75 respectively, p < 0,001). Conclusions: We propose 60 and 120 min serum insulin levels of 130 and 80 μU/mL respectively, as cut-off values for normality during OGTT in Chilean normoglycemic individuals.
dc.fechaingreso.objetodigital2024-01-12
dc.fuente.origenRepositorio UC
dc.identifier.doi10.4067/S0034-98872014000900003
dc.identifier.issn0034-9887
dc.identifier.urihttps://doi.org/10.4067/S0034-98872014000900003
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80450
dc.information.autorucEscuela de Medicina; Arancibia Verdugo Constanza Isabel; S/I; 142513
dc.information.autorucEscuela de Medicina; Galgani Fuentes Jose Eduardo; S/I; 1011272
dc.information.autorucEscuela de Medicina; Valderas Igor, Juan Patricio; S/I; 90059
dc.information.autorucEscuela de Medicina; Morales, Mauricio; S/I; 132634
dc.information.autorucEscuela de Medicina; Santos Martín, José Luis; 0000-0003-2895-0369; 1005923
dc.information.autorucEscuela de Medicina; Pollak Cornejo Felipe Antonio; S/I; 100375
dc.issue.numero9
dc.language.isoes
dc.nota.accesoContenido completo
dc.pagina.final1112
dc.pagina.inicio1106
dc.revistaRevista Médica de Chile
dc.rightsacceso abierto
dc.subjectGlucose tolerance test
dc.subjectHyperinsulinism
dc.subjectInsulin resistance
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleEvaluación de la insulinemia post carga oral de glucosa como método diagnóstico de resistencia a la insulina
dc.title.alternativeEvaluation of serum insulin levels after an oral glucose load for the diagnosis of insulin resistance
dc.typeartículo
dc.volumen142
sipa.codpersvinculados142513
sipa.codpersvinculados1011272
sipa.codpersvinculados90059
sipa.codpersvinculados132634
sipa.codpersvinculados1005923
sipa.codpersvinculados100375
sipa.trazabilidadConveris;01-10-2020
sipa.trazabilidadRepositorio UC;08-07-2021
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