Airway Count and Emphysema Assessed by Chest CT Imaging Predicts Clinical Outcome in Smokers

Simple item page
dc.contributor.authorDiaz, Alejandro A.
dc.contributor.authorValim, Clarissa
dc.contributor.authorYamashiro, Tsuneo
dc.contributor.authorSan Jose Estepar, Raul
dc.contributor.authorRoss, James C.
dc.contributor.authorMatsuoka, Shin
dc.contributor.authorBartholmai, Brian
dc.contributor.authorHatabu, Hiroto
dc.contributor.authorSilverman, Edwin K.
dc.contributor.authorWashko, George R.
dc.date.accessioned2024-01-10T12:04:08Z
dc.date.available2024-01-10T12:04:08Z
dc.date.issued2010
dc.description.abstractBackground: Recently, it has been shown that emphysematous destruction of the lung is associated with a decrease in the total number of terminal bronchioles. It is unknown whether a similar decrease is visible in the more proximal airways. We aimed to assess the relationships between proximal airway count, CT imaging measures of emphysema, and clinical prognostic factors in smokers, and to determine whether airway count predicts the BMI, airflow obstruction, dyspnea, and exercise capacity (BODE) index.
dc.description.abstractMethods: In 50 smokers, emphysema was measured on CT scans and airway branches from the third to eighth generations of the right upper lobe apical bronchus were counted manually. The sum of airway branches from the sixth to eighth generations represented the total airway count (TAC). For each subject, the BODE index was determined. We used logistic regression to assess the ability of TAC to predict a high BODE index (>= 7 points).
dc.description.abstractResults: TAC was inversely associated with emphysema (r = -0.54, P < .0001). TAC correlated with the modified Medical Research Council dyspnea score (r = -0.42, P = .004), FEV1% predicted (r = 0.52, P = .0003), 6-min walk distance (r = 0.36, P = .012), and BODE index (r = 0.55, P < .0001). The C-statistics, which correspond to the area under the receiver operating characteristic curve, for the ability of TAC alone and TAC, emphysema, and age to predict a high BODE index were 0.84 and 0.92, respectively.
dc.description.abstractConclusions: TAC is lower in subjects with greater emphysematous destruction and is a predictor of a high BODE index. These results suggest that CT imaging-based TAC may be a unique COPD-related phenotype in smokers. CHEST 2010; 138(4):880-887
dc.description.funderNational Institutes of Health
dc.description.funderParker B. Francis Foundation
dc.description.funderGlaxoSmithKline
dc.description.funderAstra-Zeneca
dc.description.funderNATIONAL HEART, LUNG, AND BLOOD INSTITUTE
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1378/chest.10-0542
dc.identifier.eissn1931-3543
dc.identifier.issn0012-3692
dc.identifier.pubmedidMEDLINE:20558554
dc.identifier.urihttps://doi.org/10.1378/chest.10-0542
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/75701
dc.identifier.wosidWOS:000283000500023
dc.information.autorucMedicina;Diaz AA;S/I;104496
dc.issue.numero4
dc.language.isoen
dc.nota.accesoSin adjunto
dc.pagina.final887
dc.pagina.inicio880
dc.publisherELSEVIER
dc.revistaCHEST
dc.rightsregistro bibliográfico
dc.subjectTHIN-SECTION CT
dc.subjectCOMPUTED-TOMOGRAPHY
dc.subjectMORPHOMETRY
dc.subjectOBSTRUCTION
dc.subjectDIMENSIONS
dc.subjectAGREEMENT
dc.subjectPATHOLOGY
dc.subjectCAPACITY
dc.subjectDYSPNEA
dc.subjectDENSITY
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAirway Count and Emphysema Assessed by Chest CT Imaging Predicts Clinical Outcome in Smokers
dc.typeartículo
dc.volumen138
sipa.codpersvinculados104496
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Airway Count and Emphysema Assessed by Chest CT Imaging Predicts Clinical Outcome in Smokers.pdf
Size:
3.25 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Artículos de revistas