Trasplante hepático: Evolución, curva de aprendizaje y resultados después de los primeros 300 casos

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dc.catalogadorgrr
dc.contributor.authorFrancisco Guerra, Juan
dc.contributor.authorLuis Quezada, Jose
dc.contributor.authorCancino, Alejandra
dc.contributor.authorArrese, Marco
dc.contributor.authorWolff, Rodrigo
dc.contributor.authorBenitez, Carlos
dc.contributor.authorCarlos Pattillo, Juan
dc.contributor.authorCristobal Gana, Juan
dc.contributor.authorConcha, Mario
dc.contributor.authorCortinez, Luis
dc.contributor.authorVera, Magdalena
dc.contributor.authorMiranda, Paula
dc.contributor.authorRubilar, Francisco
dc.contributor.authorTroncoso, Andres
dc.contributor.authorBriceno, Eduardo
dc.contributor.authorDib, Martin
dc.contributor.authorJarufe, Nicolas
dc.contributor.authorMartinez, Jorge
dc.date.accessioned2024-01-10T13:44:29Z
dc.date.available2024-01-10T13:44:29Z
dc.date.issued2019
dc.description.abstractBackground: Liver transplantation (LT) is an option for people with liver failure who cannot be cured with other therapies and for some people with liver cancer. Aim: To describe, and analyze the first 300 LT clinical results, and to establish our learning curve. Material and Methods: Retrospective cohort study with data obtained from a prospectively collected LT Program database. We included all LT performed at a single center from March 1994 to September 2017. The database gathered demographics, diagnosis, indications for LT, surgical aspects and postoperative courses. We constructed a cumulative summation test for learning curve (LC-CUSUM) using 30-day post-LT mortality. Mortality at 30 days, and actuarial 1-, and 5-year survival rate were analyzed. Results: A total of 281 patients aged 54 (0-71) years (129 women) underwent 300 LT. Ten percent of patients were younger than 18 years old. The first, second and third indications for LT were non-alcoholic steatohepatitis, chronic autoimmune hepatitis and alcoholic liver cirrhosis, respectively. Acute liver failure was the LT indication in 51 cases (17%). The overall complication rate was 71%. Infectious and biliary complications were the most common of them (47 and 31% respectively). The LC-CUSUM curve shows that the first 30 patients corresponded to the learning curve. The peri-operative mortality was 8%. Actuarial 1 and 5-year survival rates were 82 and 71.4%, respectively. Conclusions: Outcome improvement of a LT program depends on the accumulation of experience after the first 30 transplants and the peri-operative mortality directly impacted long-term survival.
dc.fechaingreso.objetodigital2024-06-25
dc.format.extent10 páginas
dc.fuente.origenWOS
dc.identifier.doi10.4067/S0034-98872019000800955
dc.identifier.eissn0717-6163
dc.identifier.issn0034-9887
dc.identifier.pubmedidMEDLINE:31859959
dc.identifier.scieloidS0034-98872019000800955
dc.identifier.scopusidSCOPUS_ID:2-s2.0-85077072129
dc.identifier.urihttp://dx.doi.org/10.4067/S0034-98872019000800955
dc.identifier.wosidWOS:000493302200002
dc.information.autorucEscuela de Medicina; Guerra Castro, Juan Francisco; S/I; 159745
dc.information.autorucEscuela de Medicina; Quezada González, José Luis; 0000-0003-0722-099X; 127016
dc.information.autorucEscuela de Medicina; Benitez Gajardo, Carlos Esteban; 0000-0002-7010-9891; 9202
dc.information.autorucEscuela de Medicina; Pattillo Silva, Juan Carlos; S/I; 18294
dc.information.autorucEscuela de Medicina; Gana Ansaldo, Juan Cristobal; 0000-0002-0400-2164; 8726
dc.information.autorucEscuela de Medicina; Concha Pinto, Mario Rodrigo; S/I; 61460
dc.information.autorucEscuela de Medicina; Cortinez Fernandez, Luis Ignacio; 0000-0001-8544-8768; 79356
dc.information.autorucEscuela de Medicina; Vera Alarcón, María Magdalena; 0000-0002-2969-3408; 226652
dc.information.autorucEscuela de Medicina; Briceno Valenzuela, Eduardo Andres; S/I; 18751
dc.information.autorucEscuela de Medicina; Dib Marambio, Martin Javier; S/I; 1103640
dc.information.autorucEscuela de Medicina; Jarufe Cassis, Nicolas Patricio; S/I; 104492
dc.information.autorucEscuela de Medicina; Arrese Jimenez, Marco Antonio; 0000-0002-0499-4191; 76095
dc.issue.numero8
dc.language.isoes
dc.nota.accesoContenido completo
dc.pagina.final964
dc.pagina.inicio955
dc.revistaRevista Médica de Chile
dc.rightsacceso abierto
dc.rights.licenseCC BY 4.0 DEED Atribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.en
dc.subjectLearning Curve
dc.subjectSurvival Analysis
dc.subjectLiver Transplantation
dc.subject610
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleTrasplante hepático: Evolución, curva de aprendizaje y resultados después de los primeros 300 casos
dc.title.alternativeLiver transplantation: Development, learning curve and results after the first 300 cases
dc.typeartículo
dc.volumen147
sipa.codpersvinculados159745
sipa.codpersvinculados127016
sipa.codpersvinculados9202
sipa.codpersvinculados18294
sipa.codpersvinculados8726
sipa.codpersvinculados61460
sipa.codpersvinculados79356
sipa.codpersvinculados226652
sipa.codpersvinculados18751
sipa.codpersvinculados1103640
sipa.codpersvinculados104492
sipa.codpersvinculados76095
sipa.indexWOS
sipa.indexPubmed
sipa.trazabilidadCarga SIPA;09-01-2024
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