Small interfering RNA for cancer treatment: overcoming hurdles in delivery

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dc.catalogadorpva
dc.contributor.authorZacconi, Flavia C. M.
dc.contributor.authorAljabali, Alaa A.A.
dc.contributor.authorChellappan, D.K.
dc.contributor.authorShrivastava, Garima
dc.contributor.authorGupta, Gaurav
dc.contributor.authorBakshi, Hamid A.
dc.contributor.authorDua, Kamal
dc.contributor.authorMetha, Meenu
dc.contributor.authorTambuwala, Murtaza M.
dc.contributor.authorAmnerkar, Nikhil D.
dc.contributor.authorCharbe, Nitin Bharat
dc.contributor.authorNegi, Poonam
dc.contributor.authorSatheeshkumar, Rajendran
dc.contributor.authorKhadse, Saurabh C.
dc.contributor.authorSatija, Saurabh
dc.date.accessioned2023-08-23T21:36:24Z
dc.date.available2023-08-23T21:36:24Z
dc.date.issued2020
dc.description.abstractIn many ways, cancer cells are different from healthy cells. A lot of tactical nano-based drug delivery systems are based on the difference between cancer and healthy cells. Currently, nanotechnology-based delivery systems are the most promising tool to deliver DNA-based products to cancer cells. This review aims to highlight the latest development in the lipids and polymeric nanocarrier for siRNA delivery to the cancer cells. It also provides the necessary information about siRNA development and its mechanism of action. Overall, this review gives us a clear picture of lipid and polymer-based drug delivery systems, which in the future could form the base to translate the basic siRNA biology into siRNA-based cancer therapies. (C) 2020 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.
dc.description.funderFONDECYT
dc.fechaingreso.objetodigital2023-08-23
dc.fuente.origenHistorial Académico
dc.identifier.citationNitin Bharat Charbe, Nikhil D. Amnerkar, Murtaza M. Tambuwala, Hamid A. Bakshi, Alaa A.A. Aljabali, Saurabh C. Khadse, Rajendran Satheeshkumar, Saurabh Satija, Meenu Metha, Dinesh Kumar Chellappan, Garima Shrivastava, Gaurav Gupta, Poonam Negi, Kamal Dua, Flavia C. Zacconi. Small interfering RNA for cancer treatment: overcoming hurdles in delivery. Science. 2020;(10005):1-1.
dc.identifier.doi10.1016/j.apsb.2020.10.005
dc.identifier.issn2211-3835
dc.identifier.urihttps://doi.org/10.1016/j.apsb.2020.10.005
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/74483
dc.identifier.wosidWOS:000595499500005
dc.information.autorucEscuela de Química; Zacconi, Flavia C. M.; 0000-0002-3676-0453; 1011127
dc.issue.numero11
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final2109
dc.pagina.inicio2075
dc.revistaActa Pharmaceutica Sinica Bes_ES
dc.rightsacceso abierto
dc.subjectSmall interfering RNA (siRNA)es_ES
dc.subjectNanomedicinees_ES
dc.subjectLiposomeses_ES
dc.subjectMicelleses_ES
dc.subjectCanceres_ES
dc.subjectPolymeres_ES
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSmall interfering RNA for cancer treatment: overcoming hurdles in deliveryes_ES
dc.typeartículo
dc.volumen10
sipa.codpersvinculados1011127
sipa.indexISI-1990-1997-2000-2001-2002-2003-2005-2006-2007-2008-2009-2010-2011-2012-2013-2014-2015
sipa.indexScopus-2010-2011-2012-2013-2014
sipa.trazabilidadHistorial Académico;09-07-2021
sipa.trazabilidadORCID;2023-08-21
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