Nuevas proyecciones fisiológicas, patológicas y terapéuticas de la leptina

Simple item page
dc.catalogadordfo
dc.contributor.authorGoldenberg, Denisse
dc.contributor.authorSantos, José Luis
dc.contributor.authorHodgson, María Isabel
dc.contributor.authorCortés, Víctor A.
dc.date.accessioned2024-01-22T16:22:21Z
dc.date.available2024-01-22T16:22:21Z
dc.date.issued2014
dc.description.abstractThe adipose tissue is an endocrine organ that produces a variety of protein hormones. One of them is leptin, which regulates several critical functions at the central nervous system such as caloric intake, basal energy expenditure, reproduction, glucose and lipid metabolism and osteogenesis. Acting at a local level, leptin modulates the immune system and promotes liver fibrogenesis. The most promising therapeutic implications of leptin will possibly be in type 1 diabetes mellitus (DM1). Its supplementation in animal models of DM1 prevents hyperglycemia and ketoacidosis. These actions depend on the activation of leptin receptors in the central nervous system and the suppression of glucagon signaling in the liver.
dc.fechaingreso.objetodigital2024-06-03
dc.fuente.origenORCID-ene24
dc.identifier.doi10.4067/S0034-98872014000600008
dc.identifier.issn0034-9887
dc.identifier.urihttp://dx.doi.org/10.4067/S0034-98872014000600008
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80896
dc.information.autorucEscuela de Medicina; Goldenberg, Denisse; S/I; 208272
dc.issue.numero6
dc.language.isoes
dc.nota.accesoContenido completo
dc.pagina.final738
dc.pagina.inicio747
dc.revistaRevista médica de Chile
dc.rightsacceso abierto
dc.subjectDiabetes mellitus
dc.subjectLeptin
dc.subjectLipodystrophy
dc.subjectObesity
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleNuevas proyecciones fisiológicas, patológicas y terapéuticas de la leptina
dc.title.alternativeNovel physiological and therapeutic implications of leptin
dc.typeartículo
dc.volumen42
sipa.codpersvinculados208272
sipa.trazabilidadConveris;20-07-2021
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Nuevas proyecciones fisiológicas.pdf
Size:
1.15 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Artículos de revistas