Multiscale analysis of water uptake and erosion in biodegradable polyarylates

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dc.contributor.authorValenzuela, Loreto M.
dc.contributor.authorZhang, Guojin
dc.contributor.authorFlach, Carol R.
dc.contributor.authorMurthy, N. Sanjeeva
dc.contributor.authorMendelsohn, Richard
dc.contributor.authorMichniak Kohn, Bozena
dc.contributor.authorKohn, Joachim
dc.date.accessioned2024-01-10T12:40:42Z
dc.date.available2024-01-10T12:40:42Z
dc.date.issued2012
dc.description.abstractThe role of hydration in degradation and erosion of materials, especially biomaterials used in scaffolds and implants, was investigated by studying the distribution of water at length scales from 0.1 nm to 0.1 mm using Raman spectroscopy, small-angle neutron scattering (SANS). Raman confocal imaging, and scanning electron microscopy (SEM). The measurements were demonstrated using L-tyrosine derived polyarylates. Bound- and free- water were characterized using their respective signatures in the Raman spectra. In the presence of deuterium oxide (D2O), H-D exchange occurred at the amide carbonyl but was not detected at the ester carbonyl. Water appeared to be present in the polymer even in regions where there was little evidence for NH to ND exchange. SANS showed that water is not uniformly dispersed in the polymer matrix. The distribution of water can be described as mass fractals in polymers with low water content (similar to 5 wt%), and surface fractals in polymers with larger water content (15-60 wt%). These fluctuations in the density of water distribution are presumed to be the precursors of the similar to 20 mu m water pockets seen by Raman confocal imaging, and also give rise to the 10-50 mu m porous network seen in SEM. The surfaces of these polymers appeared to resist erosion while the core of the films continued to erode to form a porous structure. This could be due to differences in either the density of the polymer or the solvent environment in the bulk vs. the surface, or a combination of these two factors. There was no correlation between the rate of degradation and the amount of water uptake in these polymers, and this suggests that it is the bound water and not the total amount of water that contributes to hydrolytic degradation. (c) 2011 Elsevier Ltd. All rights reserved.
dc.description.funderRESBIO (Integrated Technology Resource for Polymeric Biomaterials)
dc.description.funderNational Institutes of Health (NIBIB)
dc.description.funderNational Institutes of Health (NCMHD)
dc.description.funderNATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING
dc.fechaingreso.objetodigital08-04-2024
dc.format.extent11 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.polymdegradstab.2011.12.001
dc.identifier.issn0141-3910
dc.identifier.pubmedidMEDLINE:22368310
dc.identifier.urihttps://doi.org/10.1016/j.polymdegradstab.2011.12.001
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77339
dc.identifier.wosidWOS:000300923500027
dc.information.autorucIngeniería;Valenzuela L;S/I;18207
dc.issue.numero3
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final420
dc.pagina.inicio410
dc.publisherELSEVIER SCI LTD
dc.revistaPOLYMER DEGRADATION AND STABILITY
dc.rightsacceso restringido
dc.subjectMultiscale analysis
dc.subjectHydrolytic degradation
dc.subjectConfocal Raman spectroscopy
dc.subjectScattering
dc.subjectMicroscopy
dc.subjectPolyarylates
dc.subjectANGLE NEUTRON-SCATTERING
dc.subjectSTIMULATED DEPOLARIZATION CURRENTS
dc.subjectCONFOCAL RAMAN MICROSCOPY
dc.subjectSEMICRYSTALLINE POLYMERS
dc.subjectAQUEOUS-MEDIA
dc.subjectDEGRADATION
dc.subjectDIFFUSION
dc.subjectHYDRATION
dc.subjectPARTICLES
dc.subjectFILMS
dc.subject.ods12 Responsible Consumption and Production
dc.subject.odspa12 Producción y consumo responsable
dc.titleMultiscale analysis of water uptake and erosion in biodegradable polyarylates
dc.typeartículo
dc.volumen97
sipa.codpersvinculados18207
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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