Testing the Asthma Predictive Index as a diagnostic tool in preschoolers: analysis of a longitudinal birth cohort

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dc.catalogadorgjm
dc.contributor.authorCastro Rodríguez, José Antonio
dc.contributor.authorForno, Erick
dc.contributor.authorPadilla Pérez, Oslando
dc.contributor.authorCasanello Toledo, Paola Cecilia
dc.contributor.authorKrause Leyton, Bernardo
dc.contributor.authorBorzutzky Schachter, Arturo
dc.date.accessioned2023-05-19T20:25:08Z
dc.date.available2023-05-19T20:25:08Z
dc.date.issued2021
dc.description.abstractDiagnosing asthma in preschool children remains an unsolved challenge, at a time when early identification would allow for better education and treatment to prevent morbidity and lung function deterioration. Objective: To evaluate if the Asthma Predictive Index (API) can be used as surrogate for asthma diagnosis in preschoolers. Methods: Birth cohort of 339 pregnant women enrolled at delivery and their offspring, who were followed for atopy, wheezing, and other respiratory illnesses through 30 months of age. The API was determined at 30 months of age by the researchers; and examined its association with physician-diagnosed asthma during the first 30 months, made independently by the primary care physician not involved in the study. Results: Among 307 offspring with complete follow-up, 44 (14.3%) were API+. Maternal body mass index, maternal education, past oral contraceptive use, birthweight, placenta weight, age of daycare at 12m, gastroesophageal reflux disease at 12m, acute otitis media at 18m, bronchiolitis, croup and pneumonia, cord blood adiponectin were all associated with API+. In the multivariable analysis, API+ was associated with almost 6-fold odds of asthma diagnosis (adjusted OR= 5.7, 95% CI [2.6-12.3]), after adjusting for the relevant covariates above including respiratory infections like bronchiolitis and pneumonia. The API sensitivity was 48%, specificity 92%, 61% PPV, 88% NPV, 6.4 LR+, 0.56 LR-, 0.84 diagnosis accuracy. The adjusted odds for asthma was 11.4. Conclusions: This longitudinal birth cohort suggests, for first time, that API could be used as a diagnostic tool, not only as a prognostic tool, in toddlers and preschoolers.
dc.fechaingreso.objetodigital2023-07-14
dc.format.extent6 páginas
dc.fuente.origenORCID
dc.identifier.doi10.22541/au.161958382.20108143/v1
dc.identifier.urihttps://doi.org/10.22541/au.161958382.20108143/v1
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/67286
dc.information.autorucEscuela de Medicina; Castro Rodríguez, José Antonio; 0000-0002-0708-4281; 113247
dc.information.autorucEscuela de Medicina; Padilla Pérez, Oslando; S/I; 102063
dc.information.autorucEscuela de Medicina; Casanello Toledo, Paola Cecilia; 0000-0002-2355-1476; 146772
dc.information.autorucEscuela de Medicina; Krause Leyton, Bernardo; 0000-0002-3563-6143; 1005678
dc.information.autorucEscuela de Medicina; Borzutzky Schachter, Arturo; 0000-0002-7904-262X; 5897
dc.language.isoen
dc.nota.accesoContenido completo
dc.rightsacceso abierto
dc.subjectAsthmaes_ES
dc.subjectDiagnosises_ES
dc.subjectPreschoolerses_ES
dc.subjectRecurrent wheezinges_ES
dc.subjectAsthma predictive indexes_ES
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleTesting the Asthma Predictive Index as a diagnostic tool in preschoolers: analysis of a longitudinal birth cohortes_ES
dc.typepreprint
sipa.codpersvinculados113247
sipa.codpersvinculados102063
sipa.codpersvinculados146772
sipa.codpersvinculados1005678
sipa.codpersvinculados5897
sipa.trazabilidadORCID;14-07-2023
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