Decreased Nitric Oxide Products in the Urine of Patients Undergoing Cardiac Surgery

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dc.contributor.authorLema, Guillermo
dc.contributor.authorUrzua, Jorge
dc.contributor.authorJalil, Roberto
dc.contributor.authorCanessa, Roberto
dc.contributor.authorVogel, Andrea
dc.contributor.authorMoran, Sergio
dc.contributor.authorFajuri, Alejandro
dc.contributor.authorCarvajal, Claudia
dc.contributor.authorAeschlimann, Nicolas
dc.contributor.authorJaque, Maria P.
dc.date.accessioned2024-01-10T12:04:50Z
dc.date.available2024-01-10T12:04:50Z
dc.date.issued2009
dc.description.abstractObjective: Renal vasoconstriction has been blamed as a cause of perioperative renal dysfunction after cardiac surgery. Endothelial function is a critical determinant of vascular tonus, including vasoconstriction. The objective of this study was to establish whether the release of the endothelial vasodilator nitric oxide (NO) or NO products is altered in patients undergoing surgery with cardiopulmonary bypass in 3 different clinical conditions.
dc.description.abstractDesign: Observational and randomized prospective study.
dc.description.abstractSetting: University hospital.
dc.description.abstractParticipants: Adults and pediatric patients undergoing elective cardiac surgery with cardiopulmonary bypass.
dc.description.abstractInterventions: Three groups of patients were studied: group 1, 10 patients undergoing elective coronary artery surgery; group 2, 20 patients undergoing elective coronary artery surgery randomized to 2 hematocrit values during cardiopulmonary bypass, high (27%) and low (23%); and group 3, 10 pediatric patients undergoing surgical repair of noncyanotic cardiac defects.
dc.description.abstractMeasurements and Main Results: NO products (NO2 + NO3) and cyclic guanosine monophosphate (cGMP) in urine were measured before, during hypo- and normothermic cardiopulmonary bypass, and 1 hour postoperatively. Filtration fraction was calculated. The glomerular filtration rate and effective renal plasma flow were measured with inulin and I-131-hippuran clearances, respectively. Urinary alpha glutathione s-transferase was measured pre- and postoperatively in groups 1 and 3. NO products, as well as cGMP, decreased significantly during hypo- and normothermic cardiopulmonary bypass in all groups. This was not because of urine dilution or the degree of hemodilution. Age did not appear to alter this response. Filtration fraction decreased during cardiopulmonary bypass. Alpha glutathione s-transferase was normal pre-and postoperatively.
dc.description.abstractConclusions: Cardiac surgery with cardiopulmonary bypass is associated with a significant decrease of NO products. In the absence of kidney damage, decreased NO products could represent a physiologic response to cardiopulmonary bypass; however, endothelial dysfunction cannot be excluded. (C) 2009 Elsevier Inc. All rights reserved.
dc.description.funderFONDECYT
dc.fechaingreso.objetodigital2024-04-25
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1053/j.jvca.2008.08.017
dc.identifier.eissn1532-8422
dc.identifier.issn1053-0770
dc.identifier.pubmedidMEDLINE:19026569
dc.identifier.urihttps://doi.org/10.1053/j.jvca.2008.08.017
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/75891
dc.identifier.wosidWOS:000264999500011
dc.information.autorucMedicina;Aeschlimann N;S/I;1605
dc.information.autorucMedicina;Canessa R;S/I;55800
dc.information.autorucMedicina;Fajuri A;S/I;98943
dc.information.autorucMedicina;Jalil R;S/I;57165
dc.information.autorucMedicina;Lema G;S/I;99835
dc.information.autorucMedicina;Morán S;S/I;98562
dc.information.autorucMedicina;Vogel A;S/I;71737
dc.issue.numero2
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final194
dc.pagina.inicio188
dc.publisherW B SAUNDERS CO-ELSEVIER INC
dc.revistaJOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
dc.rightsacceso restringido
dc.subjectcardiovascular anesthesia
dc.subjectcardiopulmonary bypass
dc.subjectextracorporeal circulation
dc.subjectrenal function
dc.subjectcardiac surgery
dc.subjectGLOMERULAR-FILTRATION-RATE
dc.subjectCARDIOPULMONARY BYPASS
dc.subjectRENAL INJURY
dc.subjectBLOOD-FLOW
dc.subjectDYSFUNCTION
dc.subjectHEMODILUTION
dc.subjectCHILDREN
dc.subjectMARKER
dc.subjectPUMP
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleDecreased Nitric Oxide Products in the Urine of Patients Undergoing Cardiac Surgery
dc.typeartículo
dc.volumen23
sipa.codpersvinculados1605
sipa.codpersvinculados55800
sipa.codpersvinculados98943
sipa.codpersvinculados57165
sipa.codpersvinculados99835
sipa.codpersvinculados98562
sipa.codpersvinculados71737
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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