Design and synthesis of angucyclinone 5-aza analogues
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Date
2006
Journal Title
Journal ISSN
Volume Title
Publisher
GEORG THIEME VERLAG KG
Abstract
A highly efficient one-pot procedure for the synthesis of phenanthridine-1,7,10-triones from acylbenzoquinones and cyclic enaminones is reported. The cycloaddition reactions of these quinones with 1-trimethylsilyloxybutadiene followed by hydrolysis and oxidative processes provide entry to a variety of angucyclinone 5-aza analogues.
Description
Keywords
Michael additions, quinones, heterocycles, Diels-Alder reactions, regioselectivity, DIELS-ALDER REACTION, QUINONES, CYTOTOXICITY, HYDROQUINONES, BENZOQUINONES, ANTIBIOTICS, ACCESS, RING