Lipodistrofias primarias: presentación clínica y diagnóstico

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dc.catalogadoryvc
dc.contributor.authorCortés Mora, Víctor Antonio
dc.contributor.authorSantos Martin, José Luis
dc.date.accessioned2024-01-19T14:06:44Z
dc.date.available2024-01-19T14:06:44Z
dc.date.issued2019
dc.description.abstractLipodystrophies are a heterogeneous group of syndromes defined by a severe reduction of the adipose tissue. These can be congenital or acquired. Anatomically, they can be partial or generalized. The etiology of several lipodystrophies is well known. However, the cause of many others remains unknown. The commonest lipodystrophy worldwide is secondary to highly active anti-retroviral therapy in HIV-infected patients. By contrast, primary lipodystrophies (those not associated to any known disease or condition) are much less common and represent a diagnostic challenge. The major complications of lipodystrophies are metabolic, often resulting in severe insulin resistance, diabetes and dyslipidemia. No cure is available for lipodystrophies but the supplementation with recombinant leptin potently controls the metabolic abnormalities when there is a leptin deficiency. Herein, we review the clinical presentation, diagnostic process and therapeutic principles of the main primary lipodystrophy syndromes.
dc.fechaingreso.objetodigital2024-04-10
dc.fuente.origenORCID
dc.identifier.doi10.4067/S0034-98872019001101449
dc.identifier.urihttps://doi.org/10.4067/S0034-98872019001101449
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80630
dc.information.autorucEscuela de medicina; Santos Martín, José Luis ; 0000-0003-2895-0369 ; 1005923
dc.information.autorucEscuela de medicina ; Cortés Mora, Víctor Antonio ; 0000-0002-1658-0965 ; 7576
dc.issue.numero147
dc.language.isoes
dc.nota.accesoContenido completo
dc.pagina.final1457
dc.pagina.inicio1449
dc.revistaRevista médica de Chile
dc.rightsacceso abierto
dc.subjectAdipose Tissue
dc.subjectDiabetes Melllitus
dc.subjectInsulin Resistance
dc.subjectLeptin
dc.subjectLipodystrophy
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleLipodistrofias primarias: presentación clínica y diagnóstico
dc.typeartículo
sipa.codpersvinculados1005923
sipa.codpersvinculados7576
sipa.trazabilidadORCID;2024-01-08
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