Humoral and cellular response induced by a second booster of an inactivated SARS-CoV-2 vaccine in adults

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dc.catalogadoraba
dc.contributor.authorMelo González, Felipe
dc.contributor.authorMéndez, Constanza
dc.contributor.authorPeñaloza, H.F.
dc.contributor.authorSchultz, B.M.
dc.contributor.authorPiña Iturbe, A.
dc.contributor.authorRíos, M.
dc.contributor.authorMoreno Tapia, D.
dc.contributor.authorPereira Sánchez, P.
dc.contributor.authorLeighton, D.
dc.contributor.authorOrellana, C.
dc.contributor.authorCovarrubias, C.
dc.contributor.authorGálvez, N.M.S.
dc.contributor.authorSoto, J.A.
dc.contributor.authorDuarte, L.F.
dc.contributor.authorRivera Pérez, D.
dc.contributor.authorVázquez, Y.
dc.contributor.authorCabrera, A.
dc.contributor.authorBustos, S.
dc.contributor.authorIturriaga, C.
dc.contributor.authorUrzua, M.
dc.contributor.authorNavarrete, M.S.
dc.contributor.authorRojas, Á.
dc.contributor.authorFasce, R.
dc.contributor.authorFernández, J.
dc.contributor.authorMora, J.
dc.contributor.authorRamírez, E.
dc.contributor.authorGaete Argel, A.
dc.contributor.authorAcevedo, M.
dc.contributor.authorValiente Echeverría, F.
dc.contributor.authorSoto Rifo, R.
dc.contributor.authorWeiskopf, D.
dc.contributor.authorGrifoni, A.
dc.contributor.authorSette, A.
dc.contributor.authorZeng, G.
dc.contributor.authorMeng, W.
dc.contributor.authorGonzález Aramundiz, J.V.
dc.contributor.authorGonzález, P.A.
dc.contributor.authorAbarca, K.
dc.contributor.authorBueno, S.M.
dc.contributor.authorKalergis, A.M.
dc.date.accessioned2023-07-10T13:33:13Z
dc.date.available2023-07-10T13:33:13Z
dc.date.issued2022
dc.description.abstractThe SARS-CoV-2 Omicron variant has challenged the control of the COVID-19 pandemic even in highly vaccinated countries. While a second booster of mRNA vaccines improved the immunity against SARS-CoV-2, the humoral and cellular responses induced by a second booster of an inactivated SARS-CoV-2 vaccine have not been studied. In the context of a phase 3 clinical study, we report that a second booster of CoronaVac® increased the neutralizing response against the ancestral virus yet showed poor neutralization against the Omicron variant. Additionally, isolated PBMCs displayed equivalent activation of specific CD4+ T cells and IFN-γ production when stimulated with a mega-pool of peptides derived from the spike protein of the ancestral virus or the Omicron variant. In conclusion, a second booster dose of CoronaVac® does not improve the neutralizing response against the Omicron variant compared with the first booster dose, yet it helps maintaining a robust spike-specific CD4+ T cell response.
dc.fuente.origenORCID
dc.identifier.doi10.1101/2022.08.22.22279080
dc.identifier.urihttp://doi.org/10.1101/2022.08.22.22279080
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/74133
dc.information.autorucFacultad de Ciencias Biológicas; Melo González, Felipe Andrés; 0000-0002-3711-2407; 149763
dc.information.autorucEscuela de Medicina; Méndez Vejar, Constanza; 0000-0002-1509-4471; 1036010
dc.information.autorucFacultad de Ciencias Biológicas; Peñaloza Cerda, Hernán F.; 0000-0002-1593-678X; 186994
dc.information.autorucFacultad de Ciencias Biológicas; Schultz Lombardic, Bárbara M.; 0000-0002-6201-6978; 186964
dc.information.autorucFacultad de Ciencias Biológicas; Piña Iturbe, Luis Alejandro; 0000-0001-6190-9494; 1031369
dc.information.autorucFacultad de Ciencias Biológicas; Ríos Raggio, Mariana; S/I; 50388
dc.information.autorucFacultad de Ciencias Biológicas; Moreno Tapia, Daniela; 0000-0002-2721-8355; 246324
dc.information.autorucFacultad de Ciencias Biológicas; Pereira Sánchez, Patricia; S/I; 1282264
dc.information.autorucFacultad de Ciencias Biológicas; Leighton Scott, Diane Jean; S/I; 215457
dc.information.autorucDepartamento de Ciencias de la Salud; Orellana Encamilla, Claudia Antonia; S/I; 1240654
dc.information.autorucFacultad de Ciencias Biológicas; Gálvez Arriagada, Nicolas Marcelo Salvador; 0000-0003-2046-7882; 215440
dc.information.autorucFacultad de Ciencias Biológicas; Soto Ramírez, Jorge Andrés; 0000-0003-0335-9759; 237269
dc.information.autorucFacultad de Ciencias Biológicas; Duarte Peñaloza, Luisa Fernanda; 0000-0003-1828-1800; 1031205
dc.information.autorucFacultad de Ciencias Biológicas; Rivera Pérez, Daniela; 0000-0002-3317-5080; 1175592
dc.information.autorucFacultad de Ciencias Biológica; Cabrera Núñez, Alex; 0000-0001-9334-9217; 1078212
dc.information.autorucFacultad de Ciencias Biológicas; Bustos Crisóstomo, Sergio Eduardo; S/I; 1077639
dc.information.autorucFacultad de Medicina; Iturriaga Ortiz, Carolina; 0000-0002-8299-3864; 1058623
dc.information.autorucEscuela de Química; Urzúa Acevedo, Marcela; 0000-0002-2371-620X; 4145
dc.information.autorucEscuela de Medicina; Rojas González, Alvaro Miguel; 0009-0002-6395-4162; 5994
dc.information.autorucFacultad de Ciencias Biológicas; Fasce Pineda, Rodrigo; 0000-0002-2213-1461; 71972
dc.information.autorucEscuela de Medicina; Valiente Echeverría, Fernando Andrés; 0000-0001-9156-2516; 1006402
dc.information.autorucEscuela de Química; González Aramundiz, José Vicente; 0000-0001-7856-9211; 17164
dc.information.autorucFacultad de Ciencias Biológicas; González Muñoz, Pablo Alberto; 0000-0001-7709-6870; 15616
dc.information.autorucEscuela de Medicina; Abarca Villaseca, Katia; 0000-0003-0404-3887; 70281
dc.information.autorucFacultad de Ciencias Biológicas; Bueno Ramírez, Susan; 0000-0002-7551-8088; 113541
dc.information.autorucFacultad de Ciencias Biológicas; Kalergis Parra, Alexis Mikes; 0000-0001-7622-5263; 90610
dc.language.isoen
dc.nota.accesoSin adjunto
dc.revistamedRxives_ES
dc.rightsacceso abierto
dc.rights.licenseAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleHumoral and cellular response induced by a second booster of an inactivated SARS-CoV-2 vaccine in adults
dc.typepreprint
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sipa.codpersvinculados1036010
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