Non-rigid motion-corrected free-breathing 3D myocardial Dixon LGE imaging in a clinical setting

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dc.contributor.authorZeilinger, Martin Georg
dc.contributor.authorKunze, Karl Philipp
dc.contributor.authorMunoz, Camila
dc.contributor.authorNeji, Radhouene
dc.contributor.authorSchmidt, Michaela
dc.contributor.authorCroisille, Pierre
dc.contributor.authorHeiss, Rafael
dc.contributor.authorWuest, Wolfgang
dc.contributor.authorUder, Michael
dc.contributor.authorBotnar, Rene Michael
dc.contributor.authorTreutlein, Christoph
dc.contributor.authorPrieto, Claudia
dc.date.accessioned2024-01-10T13:10:29Z
dc.date.available2024-01-10T13:10:29Z
dc.date.issued2022
dc.description.abstractObjectives To investigate the efficacy of an in-line non-rigid motion-compensated reconstruction (NRC) in an image-navigated high-resolution three-dimensional late gadolinium enhancement (LGE) sequence with Dixon water-fat separation, in a clinical setting. Methods Forty-seven consecutive patients were enrolled prospectively and examined with 1.5 T MRI. NRC reconstructions were compared to translational motion-compensated reconstructions (TC) of the same datasets in overall and different sub-category image quality scores, diagnostic confidence, contrast ratios, LGE pattern, and semiautomatic LGE quantification. Results NRC outperformed TC in all image quality scores (p < 0.001 to 0.016; e.g., overall image quality 5/5 points vs. 4/5). Overall image quality was downgraded in only 23% of NRC datasets vs. 53% of TC datasets due to residual respiratory motion. In both reconstructions, LGE was rated as ischemic in 11 patients and non-ischemic in 10 patients, while it was absent in 26 patients. NRC delivered significantly higher LGE-to-myocardium and blood-to-myocardium contrast ratios (median 6.33 vs. 5.96, p < 0.001 and 4.88 vs. 4.66, p < 0.001, respectively). Automatically detected LGE mass was significantly lower in the NRC reconstruction (p < 0.001). Diagnostic confidence was identical in all cases, with high confidence in 89% and probable in 11% datasets for both reconstructions. No case was rated as inconclusive. Conclusions The in-line implementation of a non-rigid motion-compensated reconstruction framework improved image quality in image-navigated free-breathing, isotropic high-resolution 3D LGE imaging with undersampled spiral-like Cartesian sampling and Dixon water-fat separation compared to translational motion correction of the same datasets. The sharper depictions of LGE may lead to more accurate measures of LGE mass.
dc.description.funderProjekt DEAL
dc.fechaingreso.objetodigital2024-03-14
dc.format.extent12 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1007/s00330-022-08560-6
dc.identifier.eissn1432-1084
dc.identifier.issn0938-7994
dc.identifier.pubmedidMEDLINE:35184220
dc.identifier.urihttps://doi.org/10.1007/s00330-022-08560-6
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77866
dc.identifier.wosidWOS:000758303200001
dc.information.autorucFacultad de Ingeniería; Prieto Vasquez, Claudia Del Carmen; S/I; 14195
dc.language.isoen
dc.nota.accesocontenido completo
dc.publisherSPRINGER
dc.revistaEUROPEAN RADIOLOGY
dc.rightsacceso abierto
dc.subjectThree-dimensional imaging
dc.subjectHeart
dc.subjectMagnetic resonance imaging
dc.subjectMyocardium
dc.subjectCORONARY MR-ANGIOGRAPHY
dc.subjectLEFT ATRIUM
dc.subjectENHANCEMENT
dc.subjectCOMPENSATION
dc.subjectQUANTIFICATION
dc.subjectACQUISITION
dc.subjectIMAGES
dc.subjectSCAR
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleNon-rigid motion-corrected free-breathing 3D myocardial Dixon LGE imaging in a clinical setting
dc.typeartículo
sipa.codpersvinculados14195
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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