Features of community-acquired pneumonia in immunocompetent hospitalized adults according to the causal agent

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dc.contributor.authorSaldias Penafiel, Fernando
dc.contributor.authorGassmann Poniachik, Javiera
dc.contributor.authorCanelo Lopez, Alejandro
dc.contributor.authorDiaz Patino, Orlando
dc.date.accessioned2024-01-10T12:38:59Z
dc.date.available2024-01-10T12:38:59Z
dc.date.issued2018
dc.description.abstractBackground: Molecular biological techniques allow the identification of more pathogens associated with community-acquired pneumonia (CAP). Aim: To compare clinical and laboratory parameters of patients with CAP caused by different groups of pathogens. Material and Methods: In a prospective study, immunocompetent adult patients hospitalized with CAP were tested for the presence of a broad range of possible respiratory pathogens using bacterial cultures, polymerase chain reaction, urinary antigen testing and serology. Results: Pathogens were detected in 367 of 935 patients with CAP (39.2%). Streptococcus pneumoniae (10.7%) and influenza virus (6%) were the most frequently identified bacterial and viral pathogens, respectively. Pneumococcal pneumonia predominated in older adults, with multiple comorbidities, with elevation of inflammatory parameters and hypoxemia, like other bacterial pneumonias. Viral pneumonia predominated in elderly patients with multiple comorbidities, with a shorter hospital length of stay and lower mortality. Pneumonia associated with atypical microorganisms predominated in young adults, smokers, with subacute clinical evolution. Their hospital stays and lethality was similar to other bacterial pneumonias. Viral and classical bacterial pneumonias predominated in high risk pneumonia severity index categories. Although several variables were associated with the detection of a pathogen group, substantial overlap avoided the identification of reliable clinical predictors to distinguish etiologies. Conclusions: The clinical and radiographic characteristics were similar in pulmonary infections caused by classical bacteria, respiratory viruses and atypical microorganisms. Therefore, microbial testing for common respiratory pathogens is still necessary to optimize treatment.
dc.format.extent13 páginas
dc.fuente.origenWOS
dc.identifier.eissn0717-6163
dc.identifier.issn0034-9887
dc.identifier.pubmedidMEDLINE:30848739
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77128
dc.identifier.wosidWOS:000459046100001
dc.information.autorucMedicina;Canelo A.;S/I;213515
dc.information.autorucMedicina;Diaz O;S/I;78564
dc.information.autorucMedicina;Gassmann J.;S/I;234457
dc.information.autorucMedicina;Saldias F.;S/I;67197
dc.issue.numero12
dc.language.isoes
dc.nota.accesoSin adjunto
dc.pagina.final1383
dc.pagina.inicio1371
dc.publisherSOC MEDICA SANTIAGO
dc.revistaREVISTA MEDICA DE CHILE
dc.rightsregistro bibliográfico
dc.subjectCommunity-Acquired Infections
dc.subjectDiagnosis
dc.subjectMicrobiology
dc.subjectPneumonia
dc.subjectLEGIONELLA-PNEUMOPHILA
dc.subjectMYCOPLASMA-PNEUMONIAE
dc.subjectCLINICAL-DIAGNOSIS
dc.subjectVIRAL PATHOGENS
dc.subjectETIOLOGY
dc.subjectBACTERIAL
dc.subjectVIRUSES
dc.subjectPREVALENCE
dc.subjectPREDICTION
dc.subjectGUIDELINES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleFeatures of community-acquired pneumonia in immunocompetent hospitalized adults according to the causal agent
dc.typeartículo
dc.volumen146
sipa.codpersvinculados213515
sipa.codpersvinculados78564
sipa.codpersvinculados234457
sipa.codpersvinculados67197
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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