Helicobacter pylori-induced inflammation and epigenetic changes during gastric carcinogenesis

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dc.catalogadorpau
dc.contributor.authorValenzuela, Manuel A.
dc.contributor.authorCanales, Jimena
dc.contributor.authorCorvalán Rodríguez, Alejandro
dc.contributor.authorQuest, Andrew F. G.
dc.date.accessioned2024-06-08T16:24:35Z
dc.date.available2024-06-08T16:24:35Z
dc.date.issued2015
dc.description.abstractThe sequence of events associated with the development of gastric cancer has been described as "the gastric precancerous cascade". This cascade is a dynamic process that includes lesions, such as atrophic gastritis, intestinal metaplasia and dysplasia. According to this model, Helicobacter pylori (H. pylori) infection targets the normal gastric mucosa causing non-atrophic gastritis, an initiating lesion that can be cured by clearing H. pylori with antibiotics or that may then linger in the case of chronic infection and progress to atrophic gastritis. The presence of virulence factors in the infecting H. pylori drives the carcinogenesis process. Independent epidemiological and animal studies have confirmed the sequential progression of these precancerous lesions. Particularly long-term follow-up studies estimated a risk of 0.1% for atrophic gastritis/intestinal metaplasia and 6% in case of dysplasia for the long-term development of gastric cancer. With this in mind, a better understanding of the genetic and epigenetic changes associated with progression of the cascade is critical in determining the risk of gastric cancer associated with H. pylori infection. In this review, we will summarize some of the most relevant mechanisms and focus predominantly but not exclusively on the discussion of gene promoter methylation and miRNAs in this context.
dc.fuente.origenConveris
dc.identifier.doi10.3748/wjg.v21.i45.12742
dc.identifier.eissn2219-2840
dc.identifier.issn1007-9327
dc.identifier.pubmedid26668499
dc.identifier.urihttps://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=tsmetrics&SrcApp=tsm_test&DestApp=WOS_CPL&DestLinkType=FullRecord&KeyUT=ISI:000365966600002
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/86644
dc.identifier.wosidWOS:000365966600002
dc.information.autorucEscuela de Medicina;Corvalán Rodríguez, Alejandro; 0000-0001-5492-3853; 63885
dc.issue.numero45
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final12756
dc.pagina.inicio12742
dc.publisherBaishideng Publishing Group Inc.
dc.revistaWorld Journal of Gastroenterology
dc.rightsacceso restringido
dc.subjectEpigenetics
dc.subjectGastric cancer
dc.subjectHelicobacter pylori
dc.subjectMethylation
dc.subjectMicroRNA
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleHelicobacter pylori-induced inflammation and epigenetic changes during gastric carcinogenesis
dc.typeartículo
dc.volumen21
sipa.codpersvinculados63885
sipa.trazabilidadConveris;20-07-2021
sipa.trazabilidadORCID;2024-06-03
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