Primary germinoma of the medulla oblongata: illustrative case

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dc.catalogadorpva
dc.contributor.authorAlbiña, Pablo
dc.contributor.authorSolis, Aracelly
dc.contributor.authorLorenzoni, José
dc.contributor.authorHenny V., Pablo
dc.contributor.authorManriquez, María
dc.date.accessioned2023-05-19T20:51:07Z
dc.date.available2023-05-19T20:51:07Z
dc.date.issued2022
dc.description.abstractBackground: Primary central nervous system germinomas of the medulla oblongata are extremely rare and usually have been found in young female Asian patients. The authors present an illustrative case of a patient who presented with severe medullary and posterior cord syndrome, the first South American case published to date, to the authors' knowledge. Observations: Initially, the radiological differential diagnosis did not include this entity. The lesion was located at the obex and exhibited a well-delineated contrast enhancement without hydrocephalus. An emergency decompressive partial resection following functional limits was performed. After histological confirmation, radiotherapy was indicated, with complete remission achieved at a 6-month follow-up. The patient, however, continued to have a severe proprioceptive disorder. The literature review identified 21 other such patients. The mean age for this location was 23 years, with a strong female and Asian origin predilection. All tumors exhibited contrast enhancement, and only one presented with hydrocephalus. Lessons: In the absence of elevated tumor markers, radiological clues such as a well-delineated, contrast-enhanced lesion arising from the obex, without hydrocephalus, associated with demographic features such as young age, female sex, and Asian heritage, should evoke a high level of suspicion for this diagnosis. Gross total resection must not be attempted, because this tumor is potentially curable with high-dose radiotherapy.
dc.fechaingreso.objetodigital2023-06-05
dc.fuente.origenORCID
dc.identifier.doi10.3171/CASE21315
dc.identifier.issn2694-1902
dc.identifier.pubmedidPubMed 35733824
dc.identifier.urihttps://doi.org/10.3171/CASE21315
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/70420
dc.information.autorucEscuela de Medicina;Albiña, Pablo;0000-0002-0434-5466;172096
dc.information.autorucEscuela de Medicina;Lorenzoni, José;S/I ;80739
dc.information.autorucEscuela de Medicina;Henny V., Pablo;0000-0001-8470-8222;192951
dc.issue.numero23
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final9
dc.pagina.inicio1
dc.revistaJournal of Neurosurgery: Case Lessonses_ES
dc.rightsacceso abierto
dc.subjectGerminomaes_ES
dc.subjectMedulla oblongataes_ES
dc.subjectFourth ventriclees_ES
dc.subjectSouth Americaes_ES
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titlePrimary germinoma of the medulla oblongata: illustrative casees_ES
dc.typeartículo
dc.volumen3
sipa.codpersvinculados172096
sipa.codpersvinculados80739
sipa.codpersvinculados192951
sipa.indexPubMed
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