Merkel cell polyomavirus in non-small cell lung carcinomas from Chile

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dc.contributor.authorGheit, Tarik
dc.contributor.authorPablo Munoz, Juan
dc.contributor.authorLevican, Jorge
dc.contributor.authorGonzalez, Carolina
dc.contributor.authorAmpuero, Sandra
dc.contributor.authorParra, Barbara
dc.contributor.authorGaggero, Aldo
dc.contributor.authorCorvalan, Alejandro H.
dc.contributor.authorMeneses, Manuel
dc.contributor.authorTommasino, Massimo
dc.contributor.authorAguayo, Francisco
dc.date.accessioned2024-01-10T13:50:26Z
dc.date.available2024-01-10T13:50:26Z
dc.date.issued2012
dc.description.abstractLung cancer is a leading pathology strongly associated with the smoking habit. However, a viral etiology for a subset of patients developing lung cancer has been suggested. Polyomaviruses (PyVs) are small double stranded DNA viruses associated with the development of some human diseases. However, a causal role of these viruses in human cancer has been difficult to demonstrate. In this study, eighty-six non-small cell lung carcinomas (NSCLCs), including adenocarcinomas (AdCs) and squamous cell lung carcinomas (SQCs) from Chile were analyzed for the presence of PyVs using polymerase chain reaction (PCR). All of the specimens were positive for a fragment of the betaglobin gene. We found that 4/86 (4.7%) of lung carcinomas were positive for PyVs. After sequencing and BlastN alignment, all four cases were identified as Merkel cell polyomaviruses (MCV) that corresponded to two AdCs and two SQCs. A non-significant statistical association was found between the presence of MCV and clinic-pathological features of the patients and tumors. In addition, 1/4 (25%) of the carcinomas were actively expressing large T antigen (LT) transcripts, as demonstrated by reverse-transcriptase PCR (RT-PCR). Thus a possible role of MCV in a very small subset of patients with lung cancer cannot be ruled out and warrants more investigation. (C) 2012 Elsevier Inc. All rights reserved.
dc.description.funderFondecyt
dc.description.funderInternational Union against Cancer (UICC) through an ICRETT fellowship
dc.fechaingreso.objetodigital16-04-2024
dc.format.extent5 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.yexmp.2012.04.008
dc.identifier.eissn1096-0945
dc.identifier.issn0014-4800
dc.identifier.pubmedidMEDLINE:22537543
dc.identifier.urihttps://doi.org/10.1016/j.yexmp.2012.04.008
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79531
dc.identifier.wosidWOS:000305924000021
dc.information.autorucMedicina;Corvalan A;S/I;63885
dc.issue.numero1
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final166
dc.pagina.inicio162
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE
dc.revistaEXPERIMENTAL AND MOLECULAR PATHOLOGY
dc.rightsacceso restringido
dc.subjectLung
dc.subjectCancer
dc.subjectMCV
dc.subjectT-ANTIGEN
dc.subjectINFECTION
dc.subjectCANCER
dc.subjectEXPRESSION
dc.subjectTISSUES
dc.subjectMETHYLATION
dc.subjectVIRUS
dc.subjectDNA
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMerkel cell polyomavirus in non-small cell lung carcinomas from Chile
dc.typeartículo
dc.volumen93
sipa.codpersvinculados63885
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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