Long-Term outcome of type V lupus membranous glomerulonephritis

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dc.contributor.authorPasten, R
dc.contributor.authorMassardo, L
dc.contributor.authorRosenberg, H
dc.contributor.authorRadrigan, F
dc.contributor.authorRoessler, E
dc.contributor.authorValdivieso, A
dc.contributor.authorJacobelli, S
dc.date.accessioned2024-01-10T13:50:03Z
dc.date.available2024-01-10T13:50:03Z
dc.date.issued2005
dc.description.abstractBackground: The long-term outcome of the pure form of WHO type V lupus membranous glomerulonephritis is apparently more benign than that of other forms of lupus glomerulonepbritis. However 12% of such patients progress to terminal renal failure. The presence of proteinuria may be an indication of cytotoxic agents. Aim: To study the clinical long-term outcome of WHO type V Inpus membranous glomerulonepbritis. Material and methods: A retrospective analysis of all kidney biopsies of a University Pathology Department, with the diagnosis of WHO type V lupus membranous glomerulonephritis. Review of medical records of patients with the disease and one clinical assessment of all living patients. Results: Between 1973 and 2000, 703 kidney biopsies were done to patients with systemic lupus erytbematosus. Of these, 40 were membranous glomerulonepbritis and in 33 patients (28 women, age range 6-71 years), data on the evolution and survival was obtained. Nineteen bad type Va and the rest type Vb nephritis. Two presented with renal failure and I I with proteinuria over 3.5 g/24h. The median follow-up since the renal biopsy was 63 months (range 1-316). At the end of follow-up, four bad a creatinine clearance of less then 15 ml/h and four a clearance between 15 and 29 ml/h (one of these received a renal allograft). Eleven (33016) patients had died, mostly due to infections. Life expectancy at five years with a creatinine clearance over 15 ml/h was 75%. Bad prognostic factors were an elevated creatinine clearance over 15 ml/h was 75%. Bad prognostic factors were an elevated creatinine and high blood pressure at the moment of the biopsy. Conclusions: The clinical outcome of these patients was bad. Twelve percent reached a stage of terminal renal failure. This is in contrast with the 3% progression to a similar stage of proliferalive glomerulonephritis treated with the 3% cycloposphamide. New tberapies for this condition must be sought.
dc.format.extent10 páginas
dc.fuente.origenWOS
dc.identifier.issn0034-9887
dc.identifier.pubmedidMEDLINE:15768147
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79502
dc.identifier.wosidWOS:000227658400004
dc.information.autorucMedicina;Iacobelli S;S/I;98345
dc.information.autorucMedicina;Massardo M;S/I;100068
dc.information.autorucMedicina;Valdivieso A;S/I;99409
dc.issue.numero1
dc.language.isoes
dc.nota.accesoSin adjunto
dc.pagina.final32
dc.pagina.inicio23
dc.publisherSOC MEDICA SANTIAGO
dc.revistaREVISTA MEDICA DE CHILE
dc.rightsregistro bibliográfico
dc.subjectglomerulonephritis, membranous
dc.subjectkidney failure, chronic
dc.subjectlupus nephritis
dc.subjectCHILEAN PATIENTS
dc.subjectRENAL-FUNCTION
dc.subjectNEPHRITIS
dc.subjectERYTHEMATOSUS
dc.subjectNEPHROPATHY
dc.subjectCLASSIFICATION
dc.subjectDISEASE
dc.subjectCYCLOPHOSPHAMIDE
dc.subjectPREDICTION
dc.subjectPROGNOSIS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleLong-Term outcome of type V lupus membranous glomerulonephritis
dc.typeartículo
dc.volumen133
sipa.codpersvinculados98345
sipa.codpersvinculados100068
sipa.codpersvinculados99409
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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