Hepatitis autoinmune en una escolar asociada a la presencia de anticuerpos anti-LKM

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dc.catalogadorjlo
dc.contributor.authorLarraín Barros, Francisco Javier
dc.contributor.authorMiquel Poblete, Juan Francisco
dc.contributor.authorGonzález Bombardiere, Sergio
dc.date.accessioned2024-08-06T20:17:30Z
dc.date.available2024-08-06T20:17:30Z
dc.date.issued1997
dc.description.abstractAutoimmune hepatitis is an inflammatory liver disease characterized by dense mononuclear cell infiltrate in the portal tract, and serologically by the presence of non-organ and liver-specific autoantibodies and increased levels of gammaglobulins in the absence of a known etiology. Three subgroups of autoimmune hepatitis have been recognized, depending on the nature of the autoantibody present in the serum: Type 1 autoimmune hepatitis, associated with smooth-muscle (SMA) or antinuclear antibody (ANA) seropositivity; type 2, with anti-liver/kidney microsome antibody (anti-LKM1), and type 3, with the absence of ANA, SMA and anti-LKM1 and presence of other autoantibodies such as anti-soluble liver antigen (SLA). Subtypes of chronic autoimmune hepatitis have clinically different features and prognoses. An 8 year old female patient presented mild jaundice of insidious onset. The liver was tender and enlarged. Serologic markers for A, B, C, E, Epstein Barr and citomegalovirus were negative. The liver biopsy showed a histological picture consistent with chronic active hepatitis. High titers of anti-liver/kidney-microsome antibody were found by indirect immunofluorescence test, and this finding was confirmed by Western blot against specific liver microsome antigens. Therapy with prednisolone induced a clinical and biochemical remision after four weeks. The suspension of therapy under strict medical control produced a rapid relapse of clinical and biochemical features. The reinitiation of prednisolone was successful, and alternate-day program was started and maintained until 8 months follow-up.
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.issn0034-9887
dc.identifier.pubmedidMEDLINE:9515288
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/87299
dc.identifier.wosidWOS:A1997XP60600007
dc.information.autorucEscuela de Medicina; Larraín Barros, Francisco Javier; S/I; 98770
dc.information.autorucEscuela de Medicina; Miquel Poblete, Juan Francisco; 0000-0002-0526-4377; 72216
dc.information.autorucEscuela de Medicina; González Bombardiere, Sergio; S/I; 99856
dc.issue.numero6
dc.language.isoes
dc.nota.accesocontenido parcial
dc.pagina.final689
dc.pagina.inicio683
dc.revistaRevista Médica de Chile
dc.rightsacceso restringido
dc.subjectHepatitis antibodies
dc.subjectAutoimmune diseases
dc.subjectPrednisolone
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleHepatitis autoinmune en una escolar asociada a la presencia de anticuerpos anti-LKM
dc.title.alternativeAutoimmune hepatitis in a girl with presence of anti-liver/kidney microsome antibodies. Report of one case
dc.typeartículo
dc.volumen125
sipa.codpersvinculados98770
sipa.codpersvinculados72216
sipa.codpersvinculados99856
sipa.trazabilidadWOS;05-06-2021
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