Cardiovascular risk factors in Chilean patients with rheumatoid arthritis

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dc.contributor.authorCisternas, M
dc.contributor.authorGutierrez, MA
dc.contributor.authorKlaassen, J
dc.contributor.authorAcosta, AM
dc.contributor.authorJacobelli, S
dc.date.accessioned2024-01-10T12:04:33Z
dc.date.available2024-01-10T12:04:33Z
dc.date.issued2002
dc.description.abstractObjective. Epidemiologic studies have shown an increased mortality rate in patients with rheumatoid arthritis (RA). The most common cause of death in these patients is cardiovascular disease. We estimated the frequency of and examined risk factors for coronary artery disease in Chilean patients with RA.
dc.description.abstractMethods. Fifty-four patients with RA were studied: 87% were women, with a mean age ( standard deviation) of 51 +/- 13 yrs, 92% were rheumatoid factor positive, and 51% had radiological erosions; 32 age and sex matched healthy controls were studied. Traditional cardiovascular risk factors and RA-specific variables were determined. Lipid profile, lipoprotein(a) [Lp(a)], homocysteine, ultra-sensitive C-reactive protein (CRP), anticardiolipin (aCL), anti-B-2-glycoprotein I (anti-B-2-GPI) and antioxidized low density lipoprotein (ox-LDL) antibodies were measured.
dc.description.abstractResults. Median concentration of homocysteine was significantly higher in patients with RA than in controls: 10 (range 5.4-37.4) versus 8.3 (3.6-17.8) mumol/l (p = 0.001). Patients with RA who gave a history of cardiovascular disease had the highest concentrations of homocysteine: 15.1 (13.1-19.7) versus 9.9 (5.4-37.4) mumol/l (p = 0.001). We found no differences between patients and controls in lipid profiles or Lp(a), or for other traditional risk factors. Anti-ox-LDL, IgG aCL, and IgG anti-B-2-GPI antibody levels were similar in both groups. IgM subtypes were higher in patients with RA than in controls, but in low titers.
dc.description.abstractConclusion. Our data suggest that a high homocysteine concentration could be an important risk marker for cardiovascular disease in patients with RA.
dc.format.extent4 páginas
dc.fuente.origenWOS
dc.identifier.issn0315-162X
dc.identifier.pubmedidMEDLINE:12180719
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/75830
dc.identifier.wosidWOS:000177207200009
dc.information.autorucActividades Universitarias;Cisternas M;S/I;4233
dc.information.autorucMedicina;Gutiérrez M;S/I;68377
dc.information.autorucMedicina;Iacobelli S;S/I;98345
dc.issue.numero8
dc.language.isoen
dc.nota.accesoSin adjunto
dc.pagina.final1622
dc.pagina.inicio1619
dc.publisherJ RHEUMATOL PUBL CO
dc.revistaJOURNAL OF RHEUMATOLOGY
dc.rightsregistro bibliográfico
dc.subjectatherosclerosis
dc.subjectrheumatoid arthritis
dc.subjectlipid profiles
dc.subjecthomocysteine
dc.subjectMORTALITY
dc.subjectHOMOCYSTEINE
dc.subjectDISEASE
dc.subjectHYPERHOMOCYSTEINEMIA
dc.subjectLIPOPROTEIN
dc.subjectPLASMA
dc.subjectACID
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCardiovascular risk factors in Chilean patients with rheumatoid arthritis
dc.typeartículo
dc.volumen29
sipa.codpersvinculados4233
sipa.codpersvinculados68377
sipa.codpersvinculados98345
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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