Simultaneous T-1, T-2, and T-1 rho cardiac magnetic resonance fingerprinting for contrast agent-free myocardial tissue characterization

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dc.contributor.authorVelasco, Carlos
dc.contributor.authorCruz, Gastao
dc.contributor.authorLavin, Begona
dc.contributor.authorHua, Alina
dc.contributor.authorFotaki, Anastasia
dc.contributor.authorBotnar, Rene M.
dc.contributor.authorPrieto, Claudia
dc.date.accessioned2024-01-10T13:10:28Z
dc.date.available2024-01-10T13:10:28Z
dc.date.issued2021
dc.description.abstractPurpose: To develop a simultaneous T-1, T-2, and T-1 rho cardiac magnetic resonance fingerprinting (MRF) approach to enable comprehensive contrast agent-free myocardial tissue characterization in a single breath-hold scan.
dc.description.abstractMethods: A 2D gradient-echo electrocardiogram-triggered cardiac MRF sequence with low flip angles, varying magnetization preparation, and spiral trajectory was acquired at 1.5 T to encode T-1, T-2, and T-1 rho simultaneously. The MRF images were reconstructed using low-rank inversion, regularized with a multicontrast patch-based higher-order reconstruction. Parametric maps were generated and matched in the singular value domain to extended phase graph-based dictionaries. The proposed approach was tested in phantoms and 10 healthy subjects and compared against conventional methods in terms of coefficients of determination and best fits for the phantom study, and in terms of Bland-Altman agreement, average values and coefficient of variation of T-1, T-2, and T-1 rho for the healthy subjects study.
dc.description.abstractResults: The T-1, T-2, and T1 rho MRF values showed excellent correlation with conventional spin-echo and clinical mapping methods in phantom studies (r(2) > 0.97). Measured MRF values in myocardial tissue (mean +/- SD) were 1133 +/- 33 ms, 38.8 +/- 3.5 ms, and 52.0 +/- 4.0 ms for T-1, T-2 and T-1 rho, respectively, against 1053 +/- 47 ms, 50.4 +/- 3.9 ms, and 55.9 +/- 3.3 ms for T-1 modified Look-Locker inversion imaging, T-2 gradient and spin echo, and T-1 rho turbo field echo, respectively.
dc.description.abstractConclusion: A cardiac MRF approach for simultaneous quantification of myocardial T-1, T-2, and T-1 rho in a single breath-hold MR scan of about 16 seconds has been proposed. The approach has been investigated in phantoms and healthy subjects showing good agreement with reference spin echo measurements and conventional clinical maps.
dc.description.funderEngineering and Physical Science Research Council (EPSRC)
dc.description.funderWellcome/EPSRC Center for Medical Engineering
dc.description.funderFondecyt
dc.description.funderDepartment of Health through the National Institute for Health Research (NIHR) Comprehensive Biomedical Research Center Award
dc.description.funderKing's College London
dc.description.funderKing's College Hospital NHS Foundation Trust
dc.description.funderNIHR MedTech Co-operative for Cardiovascular Disease at Guy's and St. Thomas' NHS Foundation Trust
dc.description.funderWellcome Trust
dc.fechaingreso.objetodigital2024-04-09
dc.format.extent11 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1002/mrm.29091
dc.identifier.eissn1522-2594
dc.identifier.issn0740-3194
dc.identifier.pubmedidMEDLINE:34799854
dc.identifier.urihttps://doi.org/10.1002/mrm.29091
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77860
dc.identifier.wosidWOS:000720521400001
dc.information.autorucFacultad de Ingeniería; Prieto Vasquez, Claudia Del Carmen; S/I; 14195
dc.language.isoen
dc.nota.accesocontenido completo
dc.publisherWILEY
dc.revistaMAGNETIC RESONANCE IN MEDICINE
dc.rightsacceso abierto
dc.subjectmagnetic resonance fingerprinting
dc.subjectmapping cardiac MRI
dc.subjectmultiparametric mapping
dc.subjectT-1 rho
dc.subjectSPIN-LOCKING
dc.subjectIN-VIVO
dc.subjectARTIFACTS
dc.subjectCARTILAGE
dc.subjectSYSTEMS
dc.subjectMEDIA
dc.subjectB-0
dc.subjectMRI
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSimultaneous T-1, T-2, and T-1 rho cardiac magnetic resonance fingerprinting for contrast agent-free myocardial tissue characterization
dc.typeartículo
sipa.codpersvinculados14195
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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