Free urinary cortisol is elevated in patients with low-renin essential hypertension

Simple item page
dc.contributor.authorKrall, P
dc.contributor.authorMosso, L
dc.contributor.authorCarvajal, C
dc.contributor.authorRojas, A
dc.contributor.authorFardella, C
dc.date.accessioned2024-08-15T08:00:05Z
dc.date.available2024-08-15T08:00:05Z
dc.date.issued2004
dc.description.abstractBackground: Glucocorticoids play a key role in blood pressure (BP) control and are associated with hypertension in patients with Cushing's syndrome. A number of reports indicate that cortisol (F) may be involved in etiology of essential hypertension (EH). F can bind to the mineralocorticoid receptor, triggering both sodium and water reabsorption in kidney, increase BP and cause renin suppression. Aim: To evaluate urinary free cortisol (UFF) excretion as a potential intermediate phenotype of essential hypertension and correlate F level with plasma renin activity (PRA) and serum aldosterone (SA). Patients and Methods: We recruited 132 EH patients and 16 normotensive healthy controls. Blood samples and 24 hours urine were collected for PRA, SA and UFF analysis. Differences in UFF excretion between sexes were normalized by urinary creatinine (Creat) excretion. The upper limit of UFF/Creat was determined in normotensives considering the mean value plus 2 standard deviations. According to this value, subjects were classified as having high or normal UFF. Results: In EH patients and in normotensives, the UFF/Creat was 36.9 +/- 17.0 mug/gr and 30.9 +/- 8.8 mug/gr, respectively. The upper limit was set at 48.5 mug/gr. A high UFF/Creat was found in 20/132 EH (15%) patients and 0/16 normotensive subjects. EH patients with high UFF showed lower PRA levels than patients with normal cortisol levels (0.78 +/- 0.47 vs 1.13 +/- 0.66 ng/ml*h, respectively, p = 0.027) and lower SA values (4.52 +/- 1.65 vs 6.34 +/- 3.37 ng/dl, respectively, p = 0.018). There was a negative correlation between UFF and PRA (r = -0.176, p = 0.044) and between UFF and SA (r = -0.183, p = 0.036). Conclusions: We have identified a subgroup of EH patients with increased UFF excretion. Patients with the highest UFF showed lower renin and aldosterone levels. These data suggest a potential influence of cortisol in the genesis of hypertension.
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.eissn0717-6163
dc.identifier.issn0034-9887
dc.identifier.pubmedidMEDLINE:15543761
dc.identifier.scopusidSCOPUS_ID:0033155140
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/87437
dc.identifier.wosidWOS:000224763800005
dc.information.autorucFacultad de Medicina; Mosso Gomez, Lorena Montserrat; S/I; 88201
dc.issue.numero9
dc.language.isoes
dc.nota.accesoSin adjunto
dc.pagina.final1059
dc.pagina.inicio1053
dc.revistaREVISTA MEDICA DE CHILE
dc.rightsregistro bibliográfico
dc.subjectaldosterone
dc.subjectglucocorticoids
dc.subjecthydrocortisone
dc.subjecthypertension
dc.subjectrenin
dc.subjectPRIMARY HYPERALDOSTERONISM
dc.subjectPRIMARY ALDOSTERONISM
dc.subjectPREVALENCE
dc.subjectRESISTANCE
dc.subjectRECEPTOR
dc.titleFree urinary cortisol is elevated in patients with low-renin essential hypertension
dc.typeartículo
dc.volumen132
sipa.codpersvinculados88201
sipa.indexWOS
sipa.indexPubmed
sipa.trazabilidadCarga WOS-SCOPUS;15-08-2024
Files
Collections
Artículos de revistas