Chronic stress induces dendritic atrophy in the rat medial geniculate nucleus: Effects on auditory conditioning

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dc.contributor.authorDagnino Subiabre, Alexies
dc.contributor.authorMunoz Llancao, Pablo
dc.contributor.authorTerreros, Gonzalo
dc.contributor.authorWyneken, Ursula
dc.contributor.authorDiaz Veliz, Gabriela
dc.contributor.authorPorter, Benjamin
dc.contributor.authorKilgard, Michael P.
dc.contributor.authorAtzori, Marco
dc.contributor.authorAboitiz, Francisco
dc.date.accessioned2024-01-10T13:11:44Z
dc.date.available2024-01-10T13:11:44Z
dc.date.issued2009
dc.description.abstractChronic stress induces dendritic atrophy in the inferior colliculus (IC, auditory mesencephalon) and impairs auditory avoidance conditioning. The aim of this study was to determine in Golgi preparations and in cued fear conditioning whether stress affects other auditory components, like the thalamic medial geniculate nucleus (MG) or the posterior thalamic nucleus (PO), in Sprague-Dawley rats. Chronic restraint stress produced a significant dendritic atrophy in the MG (stress: 407 +/- 55 mu m; control: 808 +/- 120 mu m; p < 0.01) but did not affect auditory fear conditioning. The last result was in apparent contrast with the fact that stress impairs both the acquisition of auditory avoidance conditioned responses and the dendritic structure in two major nuclei of the auditory system. In order to analyze this disagreement, we investigated whether the stress-related freezing to tone occurring in the fear conditioning protocol corresponded to a conditioned or an unconditioned fear response, using changes in tone instead of light throughout conditioning trials. Chronic stress significantly enhanced visual fear conditioning in stressed animals compared to controls (stress: 58.9 +/- 8.42%, control: 23.31 +/- 8.01%; p < 0.05), but this fear enhancement was related to unconditioned fear. Conversely, chronic stress did not affect the morphology of the PO (subserving both auditory and somatosensory information) or the corresponding auditory and somatosensory unconditioned responses (acoustic startle response and escape behavior). Our results suggest that the auditory conditioned stimulus can be processed in part independently of the IC and MG in the stressed animals, and sent to the amygdala via the PO inducing unconditioned fear. Comparable alterations could be produced in major depression. (C) 2009 Elsevier B.V. All rights reserved.
dc.description.funderAnillo de Ciencia y Tecnologia
dc.description.funderUniversidad Catolica del Norte
dc.description.funderNucleo Milenio de Neurociencias Integradas
dc.fechaingreso.objetodigital20-03-2024
dc.format.extent9 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.bbr.2009.04.024
dc.identifier.eissn1872-7549
dc.identifier.issn0166-4328
dc.identifier.pubmedidMEDLINE:19397934
dc.identifier.urihttps://doi.org/10.1016/j.bbr.2009.04.024
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78088
dc.identifier.wosidWOS:000267961400013
dc.information.autorucMedicina;Aboitiz F;S/I;100165
dc.issue.numero1
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final96
dc.pagina.inicio88
dc.publisherELSEVIER
dc.revistaBEHAVIOURAL BRAIN RESEARCH
dc.rightsacceso restringido
dc.subjectStress
dc.subjectGeniculate
dc.subjectDendritic atrophy
dc.subjectFear
dc.subjectDepression
dc.subjectELEVATED PLUS-MAZE
dc.subjectDEPRESSED-PATIENTS
dc.subjectMOTOR-ACTIVITY
dc.subjectANIMAL-MODEL
dc.subjectFEAR
dc.subjectAMYGDALA
dc.subjectPROJECTIONS
dc.subjectANXIETY
dc.subjectHIPPOCAMPAL
dc.subjectEXTINCTION
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleChronic stress induces dendritic atrophy in the rat medial geniculate nucleus: Effects on auditory conditioning
dc.typeartículo
dc.volumen203
sipa.codpersvinculados100165
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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