Abnormal brain network community structure related to psychological stress in schizophrenia

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dc.catalogadorgjm
dc.contributor.authorCastro, Mariana N.
dc.contributor.authorBocaccio, Hernan
dc.contributor.authorDe Pino, Gabriela
dc.contributor.authorSanchez, Stella M.
dc.contributor.authorWainsztein, Agustina E.
dc.contributor.authorDrucaroff, Lucas
dc.contributor.authorCostanzo, Elsa Y.
dc.contributor.authorCrossley, Nicolás
dc.contributor.authorVillarreal, Mirta F.
dc.contributor.authorGuinjoan, Salvador M.
dc.date.accessioned2024-06-04T19:34:52Z
dc.date.available2024-06-04T19:34:52Z
dc.date.issued2023
dc.description.abstractRecent functional imaging studies in schizophrenia consistently report a disruption of brain connectivity. However, most of these studies analyze the brain connectivity during resting state. Since psychological stress is a major factor for the emergence of psychotic symptoms, we sought to characterize the brain connectivity reconfiguration induced by stress in schizophrenia. We tested the hypothesis that an alteration of the brain's integration-segregation dynamic could be the result of patients with schizophrenia facing psychological stress. To this end, we studied the modular organization and the reconfiguration of networks induced by a stress paradigm in forty subjects (twenty patients and twenty controls), thus analyzing the dynamics of the brain in terms of integration and segregation processes by using 3T-fMRI. Patients with schizophrenia did not show statistically significant differences during the control task compared with controls, but they showed an abnormal community structure during stress condition and an under-connected reconfiguration network with a reduction of hub nodes, suggesting a deficit of integration dynamic with a greater compromise of the right hemisphere. These results provide evidence that schizophrenia has a normal response to undemanding stimuli but shows a disruption of brain functional connectivity between key regions involved in stress response, potentially leading to altered functional brain dynamics by reducing integration capacity and showing deficits recruiting right hemisphere regions. This could in turn underlie the hyper-sensitivity to stress characteristic of schizophrenia.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.schres.2023.02.007
dc.identifier.eissn1573-2509
dc.identifier.issn0920-9964
dc.identifier.urihttps://doi.org/10.1016/j.schres.2023.02.007
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/86404
dc.identifier.wosidWOS:000942437600001
dc.information.autorucEscuela de Medicina; Crossley, Nicolás; 0000-0002-3060-656X; 11224
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final53
dc.pagina.inicio42
dc.revistaSchizophrenia Research
dc.rightsacceso restringido
dc.subjectFunctional brain connectivity
dc.subjectSchizophrenia
dc.subjectPsychological stress
dc.subjectGraph theory
dc.subjectNetworks brain dynamics
dc.subjectModularity
dc.titleAbnormal brain network community structure related to psychological stress in schizophrenia
dc.typeartículo
dc.volumen254
sipa.codpersvinculados11224
sipa.trazabilidadWOS;2023-07-06
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