Association of adrenal medullar and cortical nodular hyperplasia - A report of two cases with clinical and morpho-functional considerations

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dc.contributor.authorValdes, Gloria
dc.contributor.authorRoessler, Eric
dc.contributor.authorSalazar, Ivan
dc.contributor.authorRosenberg, Helmar
dc.contributor.authorFardella, Carlos
dc.contributor.authorMartinez, Pedro
dc.contributor.authorVelasco, Alfredo
dc.contributor.authorVelasco, Soledad
dc.contributor.authorOrellana, Pilar
dc.date.accessioned2024-01-10T12:37:41Z
dc.date.available2024-01-10T12:37:41Z
dc.date.issued2006
dc.description.abstractArterial hypertension of adrenal etiology is mainly attributed to primary hyperaldosteronism. However, subtle expressions of hyperadrenergic or glucocorticoid excess can also generate arterial hypertension. The present report describes two hypertensive patients cataloged as resistant essential hypertensives, in whom adrenal masses were found incidentally, who highlight the need to recognize these tenuous clinical or laboratory presentations. Case 1 was a 50-yr-old female with hyperadrenergic hypertension associated to a left adrenal node, normal cortisol and aldosterone:renin ratio, marginally increased urinary normetanephrine, and a positive I-131 MIBG radioisotope scan. Adrenalectomy normalized blood pressure and urinary metanephrines. Pathology showed a hyperplastic adrenal medulla associated to a multinodular cortical hyperplasia. Case 2 was a 62-yr-old female with progressive hypertension, a slight Cushing phenotype, non-suppressible hypercortisolism, normal urinary metanephrines, and bilateral adrenal nodes. Bilateral adrenalectomy and subsequent replacement normalized blood pressure and phenotypic stigmata. Pathology demonstrated bilateral cortical multinodular hyperplasia and medullary hyperplasia. The clinical study in both patients was negative for MEN. The apparently rare association of cortical and medullary lesions presented by both patients is probably overlooked in routine pathology exams, but should be meticulously searched since the crosstalk between the adrenal cortex and medulla may prompt dual abnormalities.
dc.fechaingreso.objetodigital2024-03-14
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1007/s12020-006-0019-y
dc.identifier.issn0969-711X
dc.identifier.pubmedidMEDLINE:17526953
dc.identifier.urihttps://doi.org/10.1007/s12020-006-0019-y
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76903
dc.identifier.wosidWOS:000246018300019
dc.information.autorucMedicina;Fardella C;S/I;66235
dc.information.autorucMedicina;Valdés G;S/I;98654
dc.issue.numero3
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final396
dc.pagina.inicio389
dc.publisherHUMANA PRESS INC
dc.revistaENDOCRINE
dc.rightsacceso restringido
dc.subjecthyperadrenergic hypertension
dc.subjectglucocorticoid hypertension
dc.subjectadrenal medullar hyperplasia
dc.subjectadrenal cortical adenoma
dc.subjectpheochromocytoma
dc.subjectincidentalomas
dc.subjectSUBCLINICAL CUSHINGS-SYNDROME
dc.subjectGLUCOCORTICOID-RECEPTOR
dc.subjectGLAND
dc.subjectPHEOCHROMOCYTOMA
dc.subjectCHROMAFFIN
dc.subjectADENOMA
dc.subjectRESISTANCE
dc.subjectMUTATION
dc.subjectDISEASE
dc.subjectCELLS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAssociation of adrenal medullar and cortical nodular hyperplasia - A report of two cases with clinical and morpho-functional considerations
dc.typeartículo
dc.volumen30
sipa.codpersvinculados66235
sipa.codpersvinculados98654
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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