P300 amplitude is insensitive to working memory load in schizophrenia

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dc.contributor.authorGaspar Ramos, Pablo Arturo
dc.contributor.authorRuiz Poblete, Sergio Marcelo
dc.contributor.authorZamorano Mendieta, Francisco Javier
dc.contributor.authorAltayó, Marcela
dc.contributor.authorPérez Sangüesa, Carolina Alejandra
dc.contributor.authorBosman Vittini, Conrado Arturo
dc.contributor.authorAboitiz, Francisco
dc.date.accessioned2019-10-17T18:19:53Z
dc.date.available2019-10-17T18:19:53Z
dc.date.issued2011
dc.date.updated2019-10-14T18:41:16Z
dc.description.abstractAbstract Background Working memory (WM) tasks usually elicit a P300 ERP component, whose amplitude decreases with increasing WM load. So far, this effect has not been studied in schizophrenics (SZs), a group that is considered to have an aberrant brain connectivity and impairments in WM capacity. The aim of this study was to determine the dependency of the P300 component on WM load in a sample of SZ subjects. Methods We recorded 26 subjects (13 SZ patients and their matched controls) with an 80-channel electroencephalogram. Subjects performed an N-back task, a WM paradigm that manipulates the number of items to be stored in memory. Results In healthy subjects, P300 amplitude was highest in the low WM load condition, and lowest in both the attentional control condition and the high WM load condition. In contrast, SZs evidenced low P300 amplitude in all conditions. A significant between group difference in P300 amplitude was evidenced only at the low WM load condition (1 -back), being smaller in SZs. Conclusions SZ subjects display a lower than normal P300 amplitude, which does not vary as a function of memory load. These results are consistent with a general impairment in WM capacity in these patients.
dc.fuente.origenBiomed Central
dc.identifier.citationBMC Psychiatry. 2011 Feb 15;11(1):29
dc.identifier.doi10.1186/1471-244X-11-29
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/26819
dc.issue.numeroNo. 29
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final6
dc.pagina.inicio1
dc.revistaBMC Psychiatryes_ES
dc.rightsacceso abierto
dc.rights.holderGaspar et al; licensee BioMed Central Ltd.
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.otherEsquizofreniaes_ES
dc.subject.otherEsquizofrenia - Diagnósticoes_ES
dc.subject.otherEsquizofrenia - Terapiaes_ES
dc.titleP300 amplitude is insensitive to working memory load in schizophreniaes_ES
dc.typeartículo
dc.volumenVol. 11
sipa.codpersvinculados8459
sipa.codpersvinculados100165
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