Melanocortin-4 receptor gene variants in Chilean families: association with childhood obesity and eating behavior

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dc.contributor.authorValladares, M.
dc.contributor.authorDominguez Vasquez, P.
dc.contributor.authorObregon, A. M.
dc.contributor.authorWeisstaub, G.
dc.contributor.authorBurrows, R.
dc.contributor.authorMaiz, A.
dc.contributor.authorSantos, J. L.
dc.date.accessioned2024-01-10T12:40:18Z
dc.date.available2024-01-10T12:40:18Z
dc.date.issued2010
dc.description.abstractObjective: To screen for mutations in the coding region of the melanocortin-4 receptor (MC4R) gene and to assess the association between the rs17782313 variant near MC4R with childhood obesity and eating behavior.
dc.description.abstractSubjects and methods: A cross-sectional sample of 221 obese Chilean children and 268 parents were incorporated in the study to assemble 134 case-parent trios. We performed direct sequencing of the MC4R coding region while the rs17782313 variant was genotyped by a Taqman assay. Eating behavior scores were calculated using the Child Eating Behavior and Three Factor Eating Questionnaires adapted for Chilean families.
dc.description.abstractResults: A low frequency of genetic variation in the coding region of MC4R was found in Chilean obese children (Thr150Ile mutation and polymorphisms Ile251Leu and Val103Ile). The rs17782313 variant is possibly associated with satiety responsiveness (P = 0.01) and enjoyment of food scores (P = 0.03).
dc.description.abstractConclusion: The rs17782313 variant may influence eating behavior in obese children.
dc.description.funderFONDECYT
dc.fechaingreso.objetodigital2024-05-15
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1179/147683010X12611460763643
dc.identifier.eissn1476-8305
dc.identifier.issn1028-415X
dc.identifier.pubmedidMEDLINE:20406574
dc.identifier.urihttps://doi.org/10.1179/147683010X12611460763643
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77294
dc.identifier.wosidWOS:000276534100002
dc.information.autorucMedicina;Santos JL;S/I;1005923
dc.issue.numero2
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final78
dc.pagina.inicio71
dc.publisherTAYLOR & FRANCIS LTD
dc.revistaNUTRITIONAL NEUROSCIENCE
dc.rightsacceso restringido
dc.subjectmelanocortin-4 receptor
dc.subjecteating behavior
dc.subjectobesity
dc.subjectpolymorphism
dc.subjectAGOUTI-RELATED PROTEIN
dc.subjectMC4R GENE
dc.subjectMUTATIONS
dc.subjectWEIGHT
dc.subjectENERGY
dc.subjectFAT
dc.subjectPOLYMORPHISM
dc.subjectPOPULATION
dc.subjectPREVALENCE
dc.subjectPATTERNS
dc.subject.ods03 Good Health and Well-being
dc.subject.ods02 Zero Hunger
dc.subject.odspa03 Salud y bienestar
dc.subject.odspa02 Hambre cero
dc.titleMelanocortin-4 receptor gene variants in Chilean families: association with childhood obesity and eating behavior
dc.typeartículo
dc.volumen13
sipa.codpersvinculados1005923
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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