Prevalence and isotype distribution of antiphospholipid antibodies in unselected Chilean patients with venous and arterial thrombosis
dc.contributor.author | Palomo, I | |
dc.contributor.author | Pereira, J | |
dc.contributor.author | Alarcón, M | |
dc.contributor.author | Vásquez, M | |
dc.contributor.author | Pinochet, C | |
dc.contributor.author | Vélez, MT | |
dc.contributor.author | Sandoval, J | |
dc.contributor.author | Icaza, G | |
dc.contributor.author | Pierangeli, S | |
dc.date.accessioned | 2025-01-21T01:08:11Z | |
dc.date.available | 2025-01-21T01:08:11Z | |
dc.date.issued | 2004 | |
dc.description.abstract | Antiphospholipid antibodies (aPL) are a heterogeneous family of antibodies associated with thrombotic events and other complications. The objective of this study was to investigate the prevalence of aPL in a group of Chilean patients with thrombosis. Two hundred and twenty-six patients with venous and arterial thrombosis and 95 healthy controls were studied. Anticardiolipin (aCL), anti-beta(2) glycoprotein I (anti-beta(2)GPI), and antiprothrombin (aPT) antibodies were determined. Eighty-eight out of 226 (38.9%) patients with thrombosis had some type of aPL. Fifty-seven patients (25.2%) were positive for aCL, 31 (13.7%) for aPT, and 14 (6.2%) for anti-beta(2)GPI antibodies. Twelve patients (5.3%) were positive for more than one aPL. IgG, IgM and IgA isotypes were observed in aCL, anti-beta(2)GPI, and aPT antibodies. Twenty-six out of 92 (28.3%) patients with venous thrombosis and 31/134 (23.1%) patients with arterial thrombosis were positive for aCL antibodies. With regard to the control group (4/95 = 4.2%), the odd ratios (OR) were 5.2 (1.3-19.8; p0.01) and 5.7 (1.6-22.3; p0.01), respectively. Additionally, we observed statistically significant OR with aPT and anti-beta(2)GPI antibodies; in the first, with venous and arterial thrombosis, and in the second, only with arterial thrombosis. Our results show a significant prevalence of aPL, predominantly aCL and aPT antibodies, in patients with thrombosis. Additionally, aCL and aPT antibodies appear to be a risk factor for venous and arterial thrombosis, and anti-beta(2)GPI antibodies appear to be a risk factor for arterial thrombosis. | |
dc.fuente.origen | WOS | |
dc.identifier.doi | 10.1007/s10067-003-0846-7 | |
dc.identifier.issn | 0770-3198 | |
dc.identifier.uri | https://doi.org/10.1007/s10067-003-0846-7 | |
dc.identifier.uri | https://repositorio.uc.cl/handle/11534/96436 | |
dc.identifier.wosid | WOS:000221197100007 | |
dc.issue.numero | 2 | |
dc.language.iso | en | |
dc.pagina.final | 133 | |
dc.pagina.inicio | 129 | |
dc.revista | Clinical rheumatology | |
dc.rights | acceso restringido | |
dc.subject | antiphospholipid antibodies | |
dc.subject | anti-beta(2) glycoprotein I antibodies | |
dc.subject | antiprothrombin antibodies | |
dc.subject | thrombosis | |
dc.subject.ods | 03 Good Health and Well-being | |
dc.subject.odspa | 03 Salud y bienestar | |
dc.title | Prevalence and isotype distribution of antiphospholipid antibodies in unselected Chilean patients with venous and arterial thrombosis | |
dc.type | artículo | |
dc.volumen | 23 | |
sipa.index | WOS | |
sipa.trazabilidad | WOS;2025-01-12 |