Nutrients and Gene Expression in Development

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dc.catalogadoraba
dc.contributor.authorBusso, Dolores
dc.contributor.authorSantander Grez, Nicolás Guillermo
dc.contributor.authorSalas Pérez, Francisca Lorena
dc.contributor.authorSantos Martín, José Luis
dc.contributor.editorDe Caterina, Raffaele
dc.contributor.editorMartinez, J. Alfredo
dc.contributor.editorKohlmeier, Martín
dc.date.accessioned2024-01-19T13:41:20Z
dc.date.available2024-01-19T13:41:20Z
dc.date.issued2020
dc.description.abstractDevelopment encompasses the formation of a complex organism starting from a unicellular zygote. This process requires finely tuned changes in gene expression across several cells and tissues, which may be regulated by a combination of stable and dynamic epigenetic modifications that make the DNA more or less accessible to transcriptional regulators. Diverse interdependent epigenetic mechanisms have been described, including DNA and histone methylation, histone acetylation, and silencing by micro RNAs. In the developing embryo or fetus, the epigenetic status is influenced by diverse environmental conditions, including maternal nutrition. Depending on the stage of pregnancy, gestational nutritional inadequacies may lead to congenital embryonic defects, suboptimal fetal growth, and/or reprogramming of tissues, which may determine different phenotypes or predispose individuals to chronic diseases later in life. During early pregnancy, abnormal methylation of certain genes resulting from nutritional inadequacies has been shown to increase the risk for congenital malformations that lead to perinatal death or postnatal disabilities. During mid to late pregnancy, maternal malnutrition, both undernutrition and overnutrition, has been shown to promote adaptive epigenetic changes in different organs that allow the embryo or fetus to cope with the intrauterine environment but that persist throughout life and may increase susceptibility to chronic diseases. Preconceptional nutrition in the mother, and paternal nutrition, also influence the epigenetic marks in the embryo. Nutrition seems to use epigenetics to tailor diversity and susceptibility to disease in animals and humans. Understanding nutrigenomics may be useful to understand evolution and promote health in future generations.
dc.fechaingreso.objetodigital2024-01-19
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/B978-0-12-804572-5.00057-4
dc.identifier.eisbn978-0-128-04587-9
dc.identifier.isbn978-0-12-804572-5
dc.identifier.urihttps://doi.org/10.1016/B978-0-12-804572-5.00057-4
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80615
dc.identifier.wosidWOS:000531641800059
dc.information.autorucEscuela de Medicina; Busso, Dolores; 0000-0003-2113-1926; 161700
dc.information.autorucEscuela de Medicina; Santander Grez, Nicolás Guillermo; 0000-0001-8919-833X; 163579
dc.information.autorucFacultad de Ciencias Biológicas; Salas Pérez, Francisca Lorena; ; 218143
dc.information.autorucEscuela de Medicina; Santos Martín, José Luis; 0000-0003-2895-0369; 1005923
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final430
dc.pagina.inicio423
dc.publisherACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD
dc.relation.ispartofPrinciples of Nutrigenetics and Nutrigenomics : Academic Press Elsevier, 2020, 586 páginas.
dc.revistaPRINCIPLES OF NUTRIGENETICS AND NUTRIGENOMICS: FUNDAMENTALS OF INDIVIDUALIZED NUTRITION
dc.rightsacceso restringido
dc.subjectEpigenetic
dc.subjectHemotrophic
dc.subjectHistotrophic
dc.subjectIntrauterine programming
dc.subjectMethylation
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleNutrients and Gene Expression in Development
dc.typecapítulo de libro
sipa.codpersvinculados161700
sipa.codpersvinculados163579
sipa.codpersvinculados218143
sipa.codpersvinculados1005923
sipa.trazabilidadWOS;05-06-2021
sipa.trazabilidadORCID;2024-01-08
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